Analytical information throughput

In summary, there seems to be no fluorimetric alternative to excel low-temperature techniques in analytical information throughput if chemical separations are to be avoided. Massive use in the environmental field has so far been restricted by the need to use fairly sophisticated devices such as high-resolution monochromators, cryostats, and, perhaps, dye lasers. On the other hand, a number of commercially available spectrofluorimeters provide inadequate spectral resolution for use in low-temperature spectroscopic techniques. However, given the high selectivity of such techniques, their use in the characterization of complex environmental samples will continue to grow in the foreseeable future. 

The luminol reaction has also been used for the CL determination of organic substances such as penicillins [32] and tartrate ion [30] in pharmaceutical preparations by their inhibitory effect on the luminol-iodine and luminol-periodate-manganese(II)-TEA system, respectively. As can be seen from Table 1, the results were quite satisfactory. In the indirect determination of penicillins by their inhibitory effect on the luminol-iodine system, the stopped-flow technique improves the accuracy and precision of the analytical information obtained, and also the sample throughput [32], Thus, in only 2-3 s one can obtain the whole CL signal-versus-time profile and calculate the three measured parameters formation and... 

Data systems, more broadly known as Laboratory Information Management Systems, are in almost universal use in laboratories, allowing the collection of mass data required by parallel and high-throughput analytical... 

Today s personalized medicine requires analysis of a large number of biological samples in a short period on the day they are collected from patients so that a proper informed dose adjustment can be made before subsequent dosing. The high-throughput analytical procedures developed to meet this demand are reviewed in subsequent sections covering immunoassays, HPLC alone and combined with tandem mass spectrometry detection (HPLC-MS/MS), and ultra-performance liquid chromatography with MS/MS detection (UPLC-MS/MS). 

From Analytical Chemists, a partial answer to this problem was the development and validation of new methods that permit an improvement in terms of productivity ( high-throughput ), sensitivity and selectivity, especially using very recent hyphenated analytical assays, such as HPLC-MS/MS, GC-MS/MS or further complex couplings, that can provide more complete information in a single analysis. 

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