Analyte fumonisin

Mullett W., Edward P.C., Yeung M.J., Immunoassay of fumonisins by a surface plasmon resonance biosensor, Analytical Biochemistry 1998 258 161-167. 

Major chemical contaminants implicated in food safety include pesticides, herbicides, myeotoxins and antibiotics. These analytes have been targeted by numerous groups developing SPR biosensors. As these analytes are rather small (typical molecular weight < 1,000), inhibition assay has been a preferred detection format. Examples of chemical contaminants detected by SPR biosensors include pesticides atrazine and simazine (detection limits 0.05 ng/ml and 0.1 ng/ml respectively), mycotoxin Fumonisin B1 (detection limit 50 ng/ml ), and antibiotics Sulphamethazine, Sulphadiazine (detection limits 1 ng/ml and 20 ng/ml respectively). 

W. Mullett, P. C. Edward, and M. J. Yeung, "Immunoassay of Fumonisins by a Surface Plasmon Resonance Biosensor," Analytical Biochemistry 258, 161-167 (1998). 

RD Plattner, D Weisleder, SM Poling. Analytical determination of fumonisins and other metabolites produced by Fusarium moniliforme and related species in com. In LS Jackson, JW DeVries, LB Bullerman, eds. Fumonisins in Food. New York Plenum Press, 1996, pp 57-64. 

Use of RRFs is an accepted concept in analytical chemistry and has found application in diverse areas of trace analysis where a full suite of the CRMs required for regular system calibration is not available, for example, determination of polychlorinated PCBs by GC-MS and fumonisin mycotoxins by LC-FL. There are four general scenarios for application of RRFs to marine biotoxin analyses. 

Sulyok et al. [113] reported the first validated method for the determination of 39 mycotoxins in wheat and maize by liquid chromatography with electrospray ionization-triple quadmpole mass spectrometry (LC/ESI-MS/MS) without the need for any cleanup. The 39 analytes included A and B trichothecenes (including deoxynivalenol-3-glucoside), ZEN and related derivatives, fumonisins, enniatins, ergot alkaloids, ochratoxins, aflatoxins, and moniliformin, and six trichothecene mycotoxins (NIV, DON, fusarenon-X, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, and T-2 toxin). 

Abbas, H.K. and Shier, W.T. 1992. Evaluation of biosynthetic precursors for the production of radiolabeled fumonisin B, by Fusarium moniliforme on rice medium. Abstracts of the 106th Association of Official Analytical Chemists Meeting Cincinnati, OH AOAC International Arlington, VA, pp. 236. 

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