Platelet-activating factor analogs

Hendrickson, H. S., Hendrickson, E. K., Johnson, I. D. and Farber, S. A. (1999). Intramolecularly quenched BODIPY-labeled phospholipid analogs in phospholipase A(2) and platelet-activating factor acetylhydrolase assays and in vivo fluorescence imaging. Anal. Biochem. 276, 27-35. 

Platelet Activating Factor (PAF) and PAF Analogs, Lysophosphatidic Acid and Phosphatidic Acid, Phosphatidylglycerol Cardiolipin, Sphingosine-1 -P... 

Tessner, T. and Wykle, R. (1987) Stimulated neutrophils produce an ethanolamine analog of platelet-activating factor, J. Biol. Chem. 262, 12660-12664. 

Corey, E. J. Gavai, A. V. Simple analogs of ginkgolide-B which are highly-active antagonists of platelet activating factor. Tetrahedron Lett., 1989, 30 6959-6962. 

Clark, O.E., Neally, E.W., Leiter, K.W., Finke, K.I., Miller, A.L., Smith, W.J. (2005). Putative role of platelet activating factor (PAF) analogs in cell cycle aberrations in human endothelial cells in vitro. Toxicologist 84(S-1) 160. 

Platelet-activating factor or l-alkyl-2-acetyl- n-glycero-3-phosphocholine is an ether analog of phosphatidylcholine. This biologically active lipid is of great current interest. Initially, it was found to affect aggregation of platelets and to induce a hypertensive response at very low concentrations. Recent research has revealed its role as a mediator of inflammation and of other physiologic effects on many different types of cells. 

Kunz D, Gerard NP, Gerard C. The human leukocyte platelet-activating factor recepbx, cDNA doning, cell surface expression, and construction of a novel epitope-bearing analog. J Biol Chem 1992 267 9101-9106... 

Disselnkdtter, H., Lieb. E. Oediger, H., and Wendisch, D., Synthesis of phosphono analogs of 2-0-acetyl-l-O-hexadecyl(octadecyl)-.s7i-3-glycerylphosphorylcholine (platelet-activating factor). Arch. Pharm. (Weinheim Ger). 318, 695, 1985. 

P ADP -I- l-alkyl-sn-glycero-3-phosphate <1> (<1> the product l-alkyl-2-lyso-sn-glycero-3-phosphate is the branch point intermediate in the de novo biosynthesis of ether-linked glycerolipids, plasmanylcholine, i.e. ethanolamine, and corresponding plasmalogenic analogs in membranes or platelet-activating factor PAF [2]) [1, 2]... 

Synthesis and antagonistic activities towards platelet activating factor receptor (PAFR) and glycine receptor (GlyR) of ginkgolide derivatives and analogs 13CJ01263. 

Imaging/Labeling Applications Alcohols cyclic ketones epolactaene derivatives " iejimalide carbamate derivatives lysophospholipids macrolide analogs platelet-activating factor acetylhydrolase (PAF-AH) phosphonic acid-based NAALADase inhibitors uronium salts vinblastine analog ... 

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