Analgesic, cannabis

Nabitan (39) is a cannabis-inspired analgesic whose nitrogen atom was introduced in order to improve water solubility and perhaps to affect the pharmacological profile as well. The phenolic hydroxyl of benzopyran synthon is esterified with 4-(l-piperidino)butyric acid under the influence of dicyclohexyl carbodi mi de. In addition to being hypotensive and... 

Much debate has been waged over medicinal uses of cannabis. Several therapeutic uses have been proposed, including antiemetic, analgesic, appetite stimulant, and muscle relaxant. A synthetic cannabinoid, dronabinol (Marinol) has been marketed for clinical treatment of appetite loss, nausea, and vomiting. Although synthetic, it is identical to the main psychoactive chemical constituent of cannabis (A9-THC). 

Marijuana principles Cannabis sativa L. Analgesic (indicated for... 

CS140 Formukong, E. A., A. T. Evans and F. CS151 ]. Evans. Analgesic and antiinflammatory activity of constituents of Cannabis sativa L. Inflammation (NY)... 

Cannabis resin, obtained from the flowering tops of hemp plants, contains a number of dibenzopyrans. The main active constituent is (-)-A1-3,4-numbering system is used). Cannabinol derivatives have slight pharmaceutical potential, e.g. as antiemetics and analgesics, but because of their hallucinatory effects and habituation tendency, which have led to their widespread abuse, they are not prescribed. 

By the early nineteenth century, the medicinal use of cannabis spread from Asia and the Middle East to Europe, and finally to the Americas by the mid 1800s. A Western physician named W.B. O Shaughnessey who was working in Calcutta, India, observed the use of cannabis there. After performing tests on animals, the doctor assured himself that cannabis was safe. He developed a solution of cannabis in alcohol, known as a tincture. When placed in the mouth, this tincture proved an effective analgesic (pain reliever). The doctor was also impressed with its muscle relaxant and... 

Non-medical drug use" covers, for example, the occasional use of alcohol and the regular use of the opioid analgesics. This term includes the occasional recreational use of licit and illicit drugs for their pleasurable effects (e.g. the use of amphetamines or cannabis) and outside their approved medical indications. 

CANNABIS ANALGESICS - OPIOIDS -alfentanil, fentanyl, methadone, codeine, dextromethorphan Unpredictable changes in plasma concentration. Risk of toxicity or therapeutic failure, particularly of drugs with a narrow therapeutic index Induction or inhibition of CYP3A4-mediated metabolism by cannabis. It is not yet known whether the effects are dependent on the degree of cannabis consumption Be aware. Watch for signs of toxicity, especially when cannabis use abruptly changes... 

A narcotic is a substance that produces insensibility, or a stuporous state. The most notable characteristics of narcotics are their ability to decrease the perception of pain and alter the reaction to pain, and their extremely addictive properties. Narcotics often induce a state of euphoria or extreme well being. The word narcotic is derived from the Greek word narke (meaning stupor), and traditionally applies to drugs known as opiates. Recently, the word narcotic has been adopted to include non-opiate, addictive drugs such as cocaine and cannabis. Narcotics are primarily used in medicine as pain killers and are often called narcotic analgesics. 

The seventeenth and eighteenth centuries marked the appearance not only of travel books dealing with cannabis, but also of "dispensatories" which began referring to cannabis as a medicinal agent. Typically, however, these texts were rather cautious in their advocacy of hemp as a therapeutic agent. In most instances, cannabis s antibiotic and analgesic properties were emphasized. 

Cannabis has been used as an analgesic and A -THC is a potent antiemetic and the drug has also been used as a remedy for glaucoma and in multiple sclerosis. The side-effects have, however, limited the drug in its... 

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