Amyloid precursor protein processing

Flood, F., Murphy, S., Cowburn, R., Lannfelt, L., Walker, B., Johnston, J.A. (2005) Proteasome-mediated effects of amyloid precursor protein processing at the y-secretase site. Biochem. J., 5, 545-550. 

Ulery, P.G., Beers, J., Mikhailenko, I., et al. (2000) Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer s disease. J. Biol. Chem., 275, 7410-7415. 

Runz, H., Rietdorf, J., Tomic, I., et al. (2002) Inhibition of intracellular cholesterol transport alters presenihn localization and amyloid precursor protein processing in neuronal cells. J. 

Lezoualc h F, Robert SJ. The serotonin 5-HT4 receptor and the amyloid precursor protein processing. Exp Gerontol 2003 38 159-166. 

A, Zlreng J, Xiong H (2003) Amyloid precursor protein-processing products affect mononuclear phagocyte activadon Pathways... 

Zhang SQ, Obregon D, Ehrhart J, Deng J, Tian J, Hou H et al (2013) Baicalein reduces P-amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer s disease transgenic mouse model. J Neurosci Res 91 1239-1246... 

Lim YA, Murray LA, Lai MK (2013) NeuroAiD (MLC601) and amyloid precursor protein processing. Cerebrovasc Dis 35(Suppl l) 30-37... 

Baglietto-Vargas D, Medeiros R, Martinez-Coria H, LaFerla FM, Green KN (2013) Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. Biol Psychiatry 74 357-366... 

The pharmacological activities of the various constituents of St.John s wort have been studied extensively. Hyperforin appears to be the major bioactive constituent and it acts in several ways serving as a neurotransmitter reuptake inhibitor with a broad selectivity, as a ligand for the pregnane X receptor, and as an antibacterial and antitumor agent. It also has a rapid effect on amyloid precursor protein processing, indicating a possible role in the prevention of Hypericin and the flavonoid constituents may have... 

Amyloid Precursor Protein Processing Amyloid Precursor Protein (APP), a,f,y-Secre-tases, Caspase3, Presenilin, Aph-1, Pen-2, IDE, GSK3a Alzheimer s... 

Zhang X. Cholinergic activity and amyloid precursor protein processing in aging Alzheimer s disease. Curr Drug Targets CNS Neurol Disord 2004 3 137-152. 

Peng Y, Lee DY, Jiang L, Ma Z, Schachter SC, Lemere CA (2007) Hupeizine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695. Neuroscience 150 386-395... 

Hellstrom-Lindahl E (2000) Modulation of (3-amyloid precursor protein processing and tau phosphorylation by acetylcholine receptors. Eur J Pharmacol 393 255-263... 

Gran S., Baldi A., Bussani R., Tian X., Stefanescu R., Przybylski M., Richards R, Jones S.A., Shridhar V., Clausen T., Ehrmann M. (2005) Implications of the serine protease HtrAl in amyloid precursor protein processing. Proc Natl Acad Sci USA, 102 6021-6. 

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