Mifepristone alterations

Baglietto-Vargas D, Medeiros R, Martinez-Coria H, LaFerla FM, Green KN (2013) Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. Biol Psychiatry 74 357-366... 

Heikinheimo, O., Ranta, S., Grunberg, S., Lahteenmaki, P. and Spitz, I.M. (1997) Alterations in the pituitary-thyroid and pituitary-adrenal axes - consequences of long-term mifepristone treatment. Metabolism Clinical and Experimental, 46, 292-296. 

Observational studies In a phase 2 trial of mifepristone 200 mg/day in women with advanced or recurrent endometrioid adenocarcinoma or low-grade endometrial stromal sarcoma, there were no partial or complete responses [82 ]. The most frequent grade 1 and 2 adverse reactions were anorexia, fatigue, and mood alterations which occurred in 50%, 50%, and 58% of patients respectively. The most common grade 3 adverse reactions were fatigue and dyspnea, which occurred in 25% and 17% of patients respectively. One patient had grade 4 dyspnea. There were asymptomatic rises in corticotrophin in 33%. 

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