Amyloid load

Papassotiropoulos, A., Streffer, J.R., Tsolaki, M., et al. (2003) Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer s disease associated with an intronic CYP46 polymorphism. Arch. Neurol., 60, 29-35. 

Hartman RE, Shah A, Fagan AM, Schwetye KE, Parsadanian M, Schnlman RN, Finn MB, Holtzman DM. (2006) Pomegranate jnice decreases amyloid load and improves behavior in a monse model of Alzheimer s disease. Neurobiol Dis 24 506-515. 

Mufson EJ, Chen EY, Cochran EJ, Beckett LA, Bennett DA, Kordower JH. Entorhinal cortex beta-amyloid load in individuals with mild cognitive impairment. Exp Neurol 1999 158(2) 469 190. 

Adlard, PA. et al., Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer s disease, J. Neurosci., 25,4217, 2005. 

Kim HD, Kong FK, Cao Y, Lewis TL, Kim H, Tang DC, Fukuchi K (2004) Immunizadon of Alzheimer model mice widi adenovirus vectors encoding amyloid beta-protein and GM-CSF reduces amyloid load in die brain. Neui osci Lett 370 218—223. 

AAV reduces amyloid load but may increase cerebral hemorrhages in an Alzheimer s disease mouse model. J Alzheimers Dis 27 23-38... 

Substantial reduction in amyloid load observed in APP transgenic mice treated with DP-109 for 3 months (5 mg/kg/day)... 

Archer HA, Edison P, Brooks DJ, Barnes J, Frost C, Yeatman T (2006) Amyloid load and cerebral atrophy in Alzheimer s disease all C-BIP positron emission tomography study. Ann Neurol 60 145-147... 

Another aspect to be examined in future studies is the impact of homocyteine levels on amyloid load. As this was a preliminary investigation, mice were sacrificed at 3.5 months because of the higher attrition rate occurring after 4 months of age. At this age, the animals showed only very sparse amyloid deposits, which were insufficient for evaluation of amyloid load. Another potential limitation of this study is that we evaluated mice resulting from early crossings. However, it is highly unlikely that this factor affected our results, as there were clear correlations (i.e., dose response effect) between homocysteine levels and Ap levels. Likewise, it... 

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