Solutions amprenavir oral

Solutions of sodium hydroxide and/or diluted hydrochloric acid may have been added to adjust pH. Each milliliter of AGENERASE oral solution contains 46 U vitamin E in the form of TPGS. Propylene glycol is in the formulation to achieve adequate solubility of amprenavir. The recommended daily dose of AGENERASE oral solution of 22.5 mg/kg twice daily corresponds to a propylene glycol intake of 1650 mg/kg per day. 

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Drugs that should not be combined due to overlapping toxi-cities include amprenavir oral solution plus ritonavir oral solution, atazanavir plus indinavir (due to enhanced hyperbilirubinemia), and any combination of didanosine, stavudine, and zalcitabine. Emtricitabine and lamivudine should not be combined because of their similar chemical structures, and antagonism can result when lamivudine is combined with zalcitabine, or stavudine is combined with zidovudine. 

Each mL of amprenavir oral solution contains 46 units vitamin E in the form of TPGS. 

Because of the potential risk of toxicity from the large amount of the excipient propylene glycol, amprenavir oral solution is contraindicated in infants and children below 4 years of age, pregnant women, patients with hepatic or renal failure, and patients treated with disulfiram or metronidazole (see Contraindications and Warnings). 

Use amprenavir oral solution only when amprenavir capsules or other protease inhibitor formulations are not therapeutic options. 

Oral solution Concomitant use of amprenavir oral solution and ritonavir oral solution is not recommended because the large amount of propylene glycol in amprenavir oral solution and ethanol in ritonavir oral solution may compete for the same metabolic pathway for elimination. 

Oral solution - Amprenavir oral solution is contraindicated in patients with hepatic failure... 

Amprenavir oral solution was 14% less bioavailable compared to the capsules. 

Oral solution Because of the possible toxicity associated with the large amount of propylene glycol and the lack of information on chronic exposure to large amounts of propylene glycol, use amprenavir oral solution only when amprenavir capsules or P.1078... 

Closely monitor patients who require treatment with amprenavir oral solution for... 

Use of alcoholic beverages is not recommended in patients treated with amprenavir oral solution. 

Pregnancy Category C. Amprenavir oral solution is contraindicated during pregnancy because of the potential risk of toxicity to the fetus from the high propylene glycol content. Therefore, if amprenavir is used in pregnant women, use the capsule formulation. 

If patients require treatment with amprenavir oral solution, monitor them closely for propylene glycol-associated adverse reactions, including seizures, stupor, tachycardia, hyperosmolality, lactic acidosis, renal toxicity, and hemolysis. Switch patients from amprenavir oral solution to capsules as soon as they are able to take the capsule formulation. 

James CW, McNelis KC, Matalia MD, Cohen DM, Szabo S. Central nervous system toxicity and amprenavir oral solution. Ann Pharmacother 2002 36(1) 174. 

Amprenavir may be taken with or without food however, a high-fat meal decreases the absorption of amprenavir and should be avoided. Advise adult and pediatric patients not to take supplemental vitamin E since the vitamin E content of amprenavir capsules and oral solution exceeds the Reference Daily Intake (adults, 30 units pediatrics, approximately 10 units). 

Amprenavir capsules and oral solution are not interchangeable on a mg per mg basis. 

Amprenavir PI 1200 mg bid Separate dosing from didanosine or antacids by 1 hour. Avoid high-fat meals. Rash, diarrhea, nausea See footnote 2 for concurrent drug contraindication s. Oral solution contraindicated in young children and pregnant women. 

Amprenavir is both a substrate and an inhibitor of CYP3A4 and is contraindicated with numerous other drugs (see Table 49-3 and Table 4-2). The oral solution, which contains propylene glycol, is contraindicated in young children, pregnant women, and in those using metronidazole or disulfiram. 

Fosamprenavir is a tabid phosphate prodmgof amprenavir. Amprenavir is available only as oral solution... 

Propylene glycol 50,600 mg, b.i.d. Agenerase Oral Solution (Amprenavir)... 

An optimum dosage for concurrent use has not been established. A dose increase of lopinavir/ritonavir oral solution to 533/133 mg twice daily (dose rounded to 6.5 mL) or 600/150 mg twice daily may be needed if amprenavir is given. Avoid once daily regimens. ... 

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