Diclofenac Amoxicillin

The results showed that the compounds studied with more frequency in the aquatic environment, and of which, logically, there is more information, are the antibiotics, analgesics and anti-inflammatories (like diclofenac, ibuprofen, naproxen, acetylsalicylic acid, and paracetamol), as well as the p-blocker atenolol. In the category of antibiotics, several families are included, like the macrolides (erythromycin), the fluoroquinolones (ofloxacin and ciprofloxacin), sulfonamides (sulfamethoxazole), penicillins (amoxicillin), the metronidazol, and trimethoprim. Other therapeutic groups also widely studied and frequently found in the environmental waters are the lipid regulators (gemfibrozil and bezafibrat), antiepileptic carbamaze-pine, and antidepressants (diazepam, fluoxetine, paroxetine) (see Table 3). 

Clinically important, potentially hazardous interactions with acitretin, aldesleukin, aminoglycosides, amiodarone, amoxicillin, ampicillin, aspirin, bacampicillin, bismuth, carbenicillin, chloroquine, cisplatin, cloxacillin, co-trimoxazole, dapsone, demeclocycline, dexamethasone, diclofenac, dicloxacillin, etodolac, etoricoxib, etretinate, fenoprofen, flurbiprofen, folic acid antagonists, haloperidol, hydrocortisone, ibuprofen, indomethacin, influenza vaccines, ketoprofen, ketorolac, lithium, magnesium trisalicylate, meclofenamate, mefenamic acid, methicillin, mezlocillin, minocycline, nabumetone, nafcillin, naproxen, NSAIDs, omeprazole, oxacillin, oxaprozin, oxytetracycline, paromomycin, penicillin G, penicillin V, penicillins, phenylbutazone, piperacillin, piroxicam, polypeptide antibiotics, prednisolone, prednisone, probenecid, procarbazine, rofecoxib, salicylates, salsalate, sapropterin, sulfadiazine, sulfamethoxazole, sulfapyridine, sulfasalazine, sulfisoxazole, sulindac, tazobactum, tenoxicam, tetracycline, ticarcillin, tolmetin, trimethoprim, vaccines... 

Noninterfering amiloride, acebutolol, acenocoumarol, acetaminophen, aspirin, allopuri-nol, ambroxol, amoxicillin, atenolol, bendroflumethiazide, benzbromarone, bezafibrate, biperiden, bisacodyl, bromazepam, butizide, captopril, cimetidine, ciprofloxacin, clobu-tinol, clonidine, cotinine, diazepam, diclofenac, digitoxin, digoxin, dihydrocodeine, dihy-droergotamine, diltiazem, doxepin, doxycycline, enalapril, erythromycin, fenoterol, furosemide, glibenclamide, heparin, h3qjoxanthine, ibuprofen, indomethacin, isosorbide... 

A study in healthy subjects found that diclofenac increased the clearance of amoxicillin. An isolated report describes acute interstitial nephritis with nephrotic syndrome associated with the use of naproxen and amoxicillin. 

In a study in 20 healthy subjects diclofenac 100 mg caused a slight reduction in the AUC and a slight increase in the mean renal clearance of a single 2-g dose of amoxicillin. It should be noted that there was considerable individual variation and overlapping between the two groups, and the clinical significance of this finding is unclear. 

An animal study found that diclofenac caused an 8.5-fold reduction in amoxicillin serum levels, when compared with amoxicillin alone. However, amoxicillin retained its efficacy despite lowered serum levels and it was suggested that diclofenac was unlikely to cause an increase in renal clearance of amoxicillin, nor an etfect on its liver metabolism. These studies therefore suggest that a clinically significant interaction would not be expected. 

Groppo FC, Simoes RP, Ramacciato JC, Rehder V, de Andrade ED, Mattos-Filho TR. Effect of sodium diclofenac on serum and tissue concentration of amoxicillin and on staphylococcal infection. Biol Pharm Bull (2004) 27, 52-5. 

Amoxicillin and Diclofenac in Pharmaceutical Formulations Using UV Spectral Data and the PLS Chemometric Method. Analytical Sciences 2011 27 73-78. 

Year Amoxicillin capsules FoUc acid tablets Albendazole tablets Ciprofloxacin tablets Diclofenac tablets... 

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