Aminonucleoside nephrosis

Pedraza-Chaverri, J. et ah, Garlic ameliorates hyperlipidemia in chronic aminonucleoside nephrosis, Mol. Cell. Biochem., 211, 69-77, 2000b. 

C4. Caulfield, J. P., and Farquhar, M. G., Loss of anionic sites from the glomerular basement membrane in aminonucleoside nephrosis. Lab. Invest. 39, 505-512 (1978). 

Asami T, Toyabe S, Uchiyama M (1999) Effects of glutathione on aminonucleoside nephrosis in rats. Acta Med Biol 47 9-14... 

Guoji Y, Orita M, Tashiro K, Abe H (1994) Effects of gly-cyrrhetinic acid on aminonucleoside nephrosis in rats. Naunyn-Schmiedeberg s Arch Pharmacol 349 318-323 Kimura M, Takahashi H, Ohtake Tet al. (1993) Interstrain differences in murine daunomycin-induced nephrosis. Nephron 63 193-198... 

Pedraza-Chaverri J, Granados-Silvestre MA, Medina-Campos ON, Hernandez-Pando R (1999) Effect of the in vivo catalase inhibition on aminonucleoside nephrosis. Free Rad Biol Med 27 245-253... 

Kerjaschki D,Vernillo AT,and Farquhar MG. Reduced sialylationof podocalyxin-the major sialoproteinofthe rat kidney glomerulus in aminonucleoside nephrosis.The American Journal of Pathology 118 343-349,1985. 

Herrmann A, Tozzo E, Funk J. (2012) Semi-automated quantitative image analysis of podocyte desmin immunoreactivity as a sensitive marker for acute glomerular damage in the rat puro-mycin aminonucleoside nephrosis (PAN) model. Exp. Toxicol. Pathol. 64 45-49. 

Blau, E., and Michael, A. F., 1971, Rat glomerular basement membrane composition and metabolism in aminonucleoside nephrosis, J. Lab. Clin. Med. 77 97. 

The antagonistic properties of FR 900452 have also been examined in a model of endotoxin shock, the haemodynamic and haematological manifestations of this condition closely resembling the changes induced by PAF. FR 900452 (10 mg/kg, i.v.) almost completely prevents PAF (1 /ig/kg, i.v.)-induced thrombocytopenia and leukocytopenia in rabbits [295]. It also significantly inhibits endotoxin (E. coli LPS, 30 /ig/kg, i.v.)-induced thrombocytopenia but not leukocytopenia. The same dose of FR 900452 also causes the decreased arterial blood pressure to return to normal in the endotoxin-induced rat hypotension model, an effect also reported for other PAF inhibitors [121, 274], Finally, FR 900452 has been tested for its therapeutic effect on rat nephrosis induced by aminonucleoside (puromycin, 100 mg/kg, i.p.). At 100 mg/kg twice a day orally for 6 days, the agent significantly reduces urinary protein loss in nephrotic rats [298]. 

Yayama K, Kawao M, Tujii H et aL (1993) Dup 753 prevents the development of puromycin aminonucleoside-induced nephrosis. Eur J Pharmacol 236 337-338 Yoneda H, Toriumi W, Ohmachi Y et al. (1998) Involvement of angiotensinll in development of spontaneous nephrosis in Dahl salt-sensitive rats. Eur J Pharmacol 362 213-219... 

Renal injury models such as aminonucleoside-induced nephrosis and adriamycin-induced nephrosis... 

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