Puromycin aminonucleoside

Finco DR (1997) Kidney function. In Kaneko JJ, Harvey JW, Brass ML (eds) Clinical Biochemistry of Domestic Animals, 6th edn. Academic Press, San Diego, pp 441-485 Finn WF, Porter GA (1998) Urinary biomarkers and nephrotoxicity. In DeBroe ME, Porter GA, Bennett WM, Verpooten GA (eds) Clinical Nephrotoxins. Kluwer Academic Publishers, Dordrecht, Netherlands, pp 61-99 Gherardi E, Calandra S (1982) Plasma and urinary lipids and lipoproteins during the development of nephrotic syndrome induced in the rat by puromycin aminonucleoside. Biochim Biophys Acta 710 188-196 Graff L (1983) A Handbook of Routine Urinalysis. JB Lippin-cott Company, Philadelphia... 

Nosaka K, Takahashi T, Nishi T et al. (1997) An adenosine deaminase inhibitor prevents puromycin aminonucleoside nephrotoxicity. Free Rad Biol Med 22 597-605 Park Y-S, Guijarro C, Kim Y et al. (1998) Lovastatin reduces glomerular macrophage influx and expression of monocyte chemoattractant protein-1 mRNA in nephrotic rats. Am J Kidney Dis 31 190-194... 

Yayama K, Kawao M, Tujii H et aL (1993) Dup 753 prevents the development of puromycin aminonucleoside-induced nephrosis. Eur J Pharmacol 236 337-338 Yoneda H, Toriumi W, Ohmachi Y et al. (1998) Involvement of angiotensinll in development of spontaneous nephrosis in Dahl salt-sensitive rats. Eur J Pharmacol 362 213-219... 

Immune complexes Aminoglycoside antibiotics Puromycin aminonucleoside Adriamycin Penicillamine... 

Examples heavy metals, o-penicillamine, captopril, methimazole, heroin, puromycin aminonucleoside Fluid/electrolyte imbalance... 

Figure 45- 5 Graphic example of glomerular changes in nephrotic syndrome. Scanning electron microscopic view of glomerular epithelial podocytes from a vehicle-treated rat (left) and a puromycin aminonudeoside (PAN)-treated ( 80mg/kg body wt) rat (right). Note the extensive loss of podocyte foot processes, which occurs in response to PAN-induced nephrotic syndrome. This illustrates the major cellular changes that can occur in nephrotic syndrome. GEC, glomerular epithelial cell. (From Ricardo SD, Bertrom JF, Ryan GB Antioxidants protect podocyte foot processes in puromycin aminonucleoside-treated rats. J Am Soc Nephrol 1994 4 1974-86.)...

A full account has been given of the synthesis of cordycepin via a furanoid glycal intermediate (Vol. 29, p. 258), and a similar approach has been adopted for the synthesis of the puromycin aminonucleoside (25), as outlined in Scheme 1 ... 

Marshall CB, Pippin JW, Krofft RD, Shankland SJ. 2006. Puromycin aminonucleoside induces oxidant-dependent DNA damage in podocytes in vitro and in vivo. Kidney Int 70(11) 1962-1973. 

Puromycin aminonucleoside, A-154 Puromycin hydrochloride, P-111 Puromycin, P-111 Purpurosamine A, P-20 Purpurosamine B, P-20 Purpurosamine C, D-471 Pustulan, P-112 Putidolumazine, P-113 PX Glycoprotein, P-114 4/f-Pyran, P-115 y-Pyran, P-115 1,4-Pyran, P-115 Pyrazofurin B, P-116 Pyrazofurin, P-116 Pyrazomycin B, P-116 Pyrazomycin, P-116 Pyrogallitol, C-185 Pyrrocycline C, R-155 Pyrrolosine, P-117 PZ 68, X-3... 

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