Dahl Salt Sensitive rat

Alvarez-Guerra M, Garay RC Renal Na-K-CI transporter NKCC2 in Dahl salt-sensitive rats. J Hypertens 2002 20 721. [PMID 11910309]... 

Yayama K, Kawao M, Tujii H et aL (1993) Dup 753 prevents the development of puromycin aminonucleoside-induced nephrosis. Eur J Pharmacol 236 337-338 Yoneda H, Toriumi W, Ohmachi Y et al. (1998) Involvement of angiotensinll in development of spontaneous nephrosis in Dahl salt-sensitive rats. Eur J Pharmacol 362 213-219... 

Baron, A., Riesselmann, A., and Fregly, M. J., Reduction in the elevated blood pressure of Dahl salt-sensitive rats treated chronically with L-5-hydroxytryp-tophan, Pharmacology, 42, 15, 1991. 

Abe, Y., Umemura, S., Sugimoto, K. I., Hirawa, N., Kato, Y., Yokoyama, N., Yokoyama, T., Iwai, J., and Ishii, M. 1995. Effect of green tea rich in y-aminobutyric acid on blood pressure of Dahl salt-sensitive rats. Am. J. Hypertension 8 74-79. 

Roman, R.J., M. Alonso-Galicia, and T.W. Wilson (1997). Renal P450 metabolites of arachidonic acid and the development of hypertension in Dahl salt-sensitive rats. Am. J. Hypertens. 10,63S-67S. 

Altered renal P-450 metabolism of arachidonic acid in dahl salt-sensitive rats. Am. J. Physiol. 267, R579-R589. 

Watanabe, H. N. Kashimoto J. Kajimura K. Kamiya. A miso (Japanese soybean paste) diet conferred greater protection against hypertension than a sodium chloride diet in dahl salt-sensitive rats. Hypertension Res. 2006, 29, 731—738. 

Because of the potential for ANF to be involved in blood pressure control, several investigators have studied its effects on the cardiovascular system of normal and hypertensive animals. In anesthetized normotensive and spontaneously hypertensive rats, atrial extract decreased arterial blood pressure in association with a decrease in both total peripheral resistance and cardiac contractility.il Also, a negative chronotropic effect has been reported in rats.H Dahl salt-sensitive rats appear to have greater amounts of ANF in their atria, but are hyporesponsive when exogenous material is injected.90 Results from this study also suggest an increase in renal papillary plasma flow and a washout of the medullary osmotic gradient, factors which could contribute significantly to the associated natriuresis and diuresis. Increased medullary and inner cortical blood flow also were reported in normotensive rats.118... 

Many studies indicate an association between high blood pressure in experimental animals and abnormalities in urinary prostanoid excretion, a presumed index of the balance between renal prostanoid production and catabolism in vivo, and in rates of prostanoid synthesis and catabolism by renal structures and subcellular fractions in vitro. The urinary excretion of PGE2 is unchanged or decreased in spontaneously hypertensive rats, decreased in genetically hypertensive mice, in female genetically hypertensive rats (New Zealand strain) and in hypertensive Dahl salt-sensitive rats and either unchanged" or increased" in rats with two kidney-one clip... 

Doi, R., Masuyama, T., Yamamoto, K., Doi, Y., Mano, T., Sakata, Y, Ono, K., Kuzuya, T., Hirota, S., Koyama, T., Miwa, T., and Hori, M. (2000) Development of different phenotypes of hypertensive heart failure systohc versus diastohc failure in Dahl salt-sensitive rats./. Hypertens. 18, 111—120. 

Wilson TW, Alonso-Galicia M, Roman RJ (1998) Effects of lipid-lowering agents in the Dahl salt-sensitive rat. Hypertension 31 225-231... 

Cilazapril (10 mg/kg x day) abolished myocardial reactive oxygen species in Dahl salt-sensitive rats on high-salt (8% NaCl for 10 weeks) diet (Tsutsui et al. 2001). 

Nonaka-Sarukawa, M., Okada, T., Ito, T., Yamamoto, K., Yoshioka, X, Nomoto, X, Hojo, Y, Shimpo, M., Urabe, M., Mizukami, H., Kume, A., Keda, U., Shlmada, K., and Ozawa, K. 2008. Adeno-associated virus vector-mediated systemic interleukm-10 expression ameliorates hypertensive organ damage in Dahl salt-sensitive rats. Journal of Gene Medicine, 10,368-374. 

Hoshlno-Takao, L, Fujll, S., Ishh, A., Han, L. K., Okuda, H. Kumao, T. (2008). Effects of mannoohgosaccharldes from coffee mannan on blood pressure In dahl salt-sensitive rats. Journal of Nutritional Science and Vitaminology, 54, 181-184. 

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