2- Aminoethanol, reaction with

Kinetic studies of hexacyanoferrate(III) oxidations have included the much-studied reaction with iodide and oxidation of the TICI2 anion, of hydrazine and hydrazinium, and of phenylhydrazine and 4-bromophenylhydrazine. These last reactions proceed by outer-sphere mechanisms, and conform to Marcus s theory. Catalyzed [Fe(CN)g] oxidations have included chlororuthenium-catalyzed oxidation of cyclohexanol, ruthenium(III)-catalyzed oxidation of 2-aminoethanol and of 3-aminopropanol, ruthenium(VI)-catalyzed oxidation of lactate, tartrate, and glycolate, and osmium(VIII)-catalyzed oxidation of benzyl alcohol and benzylamine. ... 

Norepinephrine Norepinephrine, L-l-(3,4-dihydroxyphenyl)-2-aminoethanol (11.1.4), is synthesized by two methods starting from 3,4-dihydroxybenzaldehyde. According to the first method, the indicated aldehyde is transformed into the cyanohydrin (11.1.3) by reaction with hydrogen cyanide, which is then reduced into norepinephrine (11.1.5) [11,12]. 

Trithioisatoic anhydrides were also cyclized to thiazolo-[2,3-bjquinazolines (255) upon reaction with 2-aminoethanol or l-amino-2-dimethoxyethane (80PHA124 83ZC215). Double ring closures occured when jV-(2-methoxycarbonylphenyl)thiocarbamate reacted with 2-aminothioethanol (82JIC1117) to give 256. Thermal molecular rearrange-... 

Instead of halogen atoms, other functional groups can be attacked by the nitrogen and oxygen atom. The reaction of 2-aminoethanol 118 with [1-di ketones 119 led to the corresponding enamines, which reacted further with acetic... 

The OPA method is based on the formation of a highly fluorescent isoindole derivative by reaction with o-phthalaldehyde and 2-aminoethanol in mildly basic aqueous solution (331. The advantage of this technique is that a large variety of thiols and other reduced sulfur compounds can be detected at subnanomolar to nanomolar concentrations. Its disadvantage is that the fluorescent derivative, which preserves the thiol in its reduced stage, is unstable and must be formed just prior to injection. These characteristics preclude the delayed analysis (e.g., in the laboratoiy) of large numbers of samples collected in the field. 

An improved electrochemical synthesis of chiral oxazolidin-2-ones from 1,2-aminoalcohols was achieved by reaction with C02 and electrogenerated acetonitrile anion <02TL5863>. The reaction of A-protected amino acids with paraformaldehyde was greatly accelerated by microwave irradiation <02TL9461>. Oxazolidin-2-ones were synthesised by sulfur assisted thiocarbonylation of 2-aminoethanols with carbon monoxide and subsequent oxidative cyclisation with molecular oxygen <02T7805>. 

The reaction of 2-aminoethanol 372 with ketones 373 affords the pyridazino-oxazepine 374 (Scheme 202) via intermediate formation of the corresponding enamines <2003PS199, CHEC-III(13.09.9.1)273>. 

A hydroformylation-cyclocondensation of iV-alkenylpropane-1,3-diamines, such as 159 (prepared by reductive amination of the appropriate unsaturated aldehyde with either propane-1,2-diamine or 2-aminoethanol and subsequent borohydride reduction), in the presence of PPh3 and BIPHENPHOS as ligand provided different reaction products depending on the H2/CO ratio <1999AJC1131>. The bicyclic system 160 was accompanied by 10% branched 162 when H2/CO was 1 1 (Scheme 66). Reaction with H2/CO in a 1 5 ratio provided solely the bicyclic system, while only a mixture of monoalcohols 161 and 162 was isolated when the reaction was performed in the absence of PPh3. 

The ferrocenylphosphine-silver complex catalyzes the aldol-type reaction of tosylmethyl isocyanide 71 with aldehydes with higher stereoselectivity than the gold complex (Scheme 2-59) [84]. The reaction with several aldehydes produces trans-4-tosyloxazolines 72 in up to 86% ee, which can be converted into optically active l-alkyl-2-aminoethanols by reduction with LiAlH4. 

The reaction of resorcarenes II with suitable diamines and CH2O under high dilution conditions leads to l,2 3,4-bis-bridged tetrabenzoxazines , or in the case of ethylene diamine to a head-to-head connected bis-resorcarene . K 2-aminoalcohols are used in the Mannich reaction with resorcarenes, either benzoxazines, oxazine or oxazolidine rings can be formed. In the case of aminoethanol, predominantly the benzoxazine 78 (R = CH2CH2OH) was detected in solution, while oxazolidines were predominantly obtained with 2-alkylaminoethanols . 

Novel organic molecules derived from L-proline and amines or amino alcohols, were found to catalyse the asymmetric direct aldol reaction with high efficiency. Notably those containing L-proline amide moiety and terminal hydroxyl group could catalyse direct asymmetric aldol reactions of aldehydes in neat acetone with excellent results[1]. Catalyst (1), prepared from L-proline and (IS, 2Y)-diphcnyl-2-aminoethanol, exhibits high enantioselectivities of up to 93% ee for aromatic aldehydes and up to >99% ee for aliphatic aldehydes. 

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