2- Aminoethanethiole hydrochloride

Reaction of 2-aminoethanethiol hydrochloride with hydroxymethylfurazan 61 in 48% aqueous hydrobromic acid (reflux, 24 h) gave a salt that on treatment with an equimolar amount of 3,4-dimethoxy-l,2,5-thiadiazole 1,1-dioxide and another amine gave compound 62 (84USP4471122) (Scheme 30). 

Glycoconjugate polymers were prepared by the copolymerization of different monomers, and immobilized on cellulose membrane for affinity separation. The synthesis of the mannose-based monomer involved the photochemical addition of 2-aminoethanethiol hydrochloride onto an alkenyl a-D-mannoside derivative 36. Of note, 37 was formed in a quantitative yield upon irradiation in MeOH at room temperature, with no competitive addition of the amino group onto the alkene (Scheme 3.24) [59]. 

A -Thiazolin-2-yl) compounds 196 were obtained by reaction of the corresponding 6-cyano derivatives 197 with stochiometric quantities of 2-aminoethanethiol hydrochloride and triethylamine in ethanol as shown in Scheme 76 <2004EJM815>. 

Aromatic dicarboxyl-terminated PMMA was prepared in two different ways [ 155]. Using 2-mercap to ethanol or 2-aminoethanethiol hydrochloride, -OH or -NH2 end-groups were introduced, respectively. Finally, reaction with trimetallic anhydride provides the desired macromonomers. The following scheme describes these procedures (Scheme 45). 

Fig. 1 shows PL spectra of as-synthesized CdSe/ZnS nanorystals in chloroform and solubilized in water by 2-aminoethanethiol hydrochloride, cysteine, mercaptoacetic acid and 11-mercaptoundecanoic acid. The general effect of water solubilization results in a noticeable decrease of PL intensity as compared to the original nanocrystals in chloroform. 

Methylmercaptoethylamine. At room temperature, 2-aminoethanethiol hydrochloride (5.68 g, 0.05 mole) is dissolved in dry ethanol (60 mL). To this solution, a freshly prepared ethanolic solution of sodium ethoxide [120 mL EtOH -t- 2.30 g (0.10 mole) of sodium metal] is added dropwise with stirring so that the temperature of the mixture does not rise above 30°C. This mixture is stirred for 30 min and then filtered to remove the NaCl that precipitated. The filtrate is concentrated under reduced pressure to about 80 mL. Freshly distilled methyl iodide (7.097 g, 0.05 mole) is then added slowly with stirring. After stirring for 6 h at 60-65°C, the solvent is removed under reduced pressure, giving a pale yellow liquid that contained a white solid (Nal). Saturated aqueous sodium hydroxide (25 mL) is added to the yellow liquid at 20°C and the mixture is stirred for 5 min and stored at 10°C. A pale yellow oil separated within 1.5 h. The oil is extracted with ether (2 x 20 mL) and the combined extracts are dried over anhydrous magnesium sulfate overnight, filtered, and the ether is subsequently removed under reduced pressure to obtain 2-methylmercaptoethylamine as a yellow liquid. Yield = 2.65 g, (58%). 

A soln. of trichloromethanesulfenyl chloride in abs. ethanol added dropwise to a cooled vigorously stirred soln. of 2-aminoethanethiol hydrochloride in the same solvent at such a rate that the temp, does not exceed 50 , stirring continued for 1 hr. 2,2 -dithiobisethylamine dihydrochloride. Y 89%. T. P. Johnston and A. Gallagher, J. Org. Ghem. 26, 3780 (1961). 

SPR sensor fabrication (10-spot format). Ligands synthesized in solution phase (0.12 mmol) are dissolved in DMF (4 mL), and 2-aminoethanethiol hydrochloride (18.51 mg, 0.24 mmol) and NaHCOs (10 mg, 0.12 mmol in 1 mL of water) added. The reaction proceeds for 15 h at 90°C with vigorous stirring and followed by TLC until completion, when the product is precipitated with water, collected on 42-grade ashless filter paper, and dried in the oven at 50°C for 1 h. Gold-coated glass slides or prisms are immersed in solution C and allowed to react for 2-12 h at room temperature, after which they are washed and stored in the respective solvent systems. 

From 2-Aminoethanethiol and Related Compounds. The condensation of glyoxylic acid and 2-aminoethanethiol (cysteamine) or L-cysteine (267 R = COgH) yields the appropriate thiazolidine (269 R = H, COaH, or COaMe). The intermediate linear adducts (268) may be isolated when the hydrochlorides or oxalates of the mercaptoamines are used in the condensation they are subsequently cyclized to (269) by alkali. The acyclic... 

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