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2- Aminoethanethiol

Reaction of 2-aminoethanethiol hydrochloride with hydroxymethylfurazan 61 in 48% aqueous hydrobromic acid (reflux, 24 h) gave a salt that on treatment with an equimolar amount of 3,4-dimethoxy-l,2,5-thiadiazole 1,1-dioxide and another amine gave compound 62 (84USP4471122) (Scheme 30). [Pg.82]

The N,S-chelate 2-aminoethanethiolate (aet-) forms stable cobalt(III) complexes, including clusters where the S can take on a bridging role. Reaction of [Co(NH3)5C1]2+ with Ni(aet)2 in water for several hours affords the black tetranuclear compound Co4(aet)8, which features act in simple chelate and bridging roles (245).1083 The simple monomeric complex [Co(aet)2(en)]+ has been reported 1084 when heated in water at 50 °C, the trimer Co Co(aet)3 2 is one product, with the central Co surrounded by six bridging S atoms. [Pg.96]

The demonstration of the formation of a hexanuclear zinc complex with the S-donor ligand 2-aminoethanethiolate, containing Zn3S3 and Zn4S4 cyclic units, contributes to the building up of a pattern of polynuclear complex formation based on coordination preferences of the metal ions involved (320) - reaction of Zn2+ with salicylideneamino ligands and pyrazine can give linear tetranuclear complexes (321). Another hexanuclear zinc complex appears in the section on supramolecular chemistry below (Section VII.D). [Pg.117]

Fife et ai, 1975. The reference reaction is attack by 2-aminoethanethiolate anion (pA, 8.3) onp-nitrophenyl N-methyl-N-phenylcarbamate, corrected to pK 8.7... [Pg.253]

The reaction mode depends mainly on the choice of the base and reaction conditions, but route B is usually more common. Thus, tetrahydro-l,4-thiazine derivative 157 the structure of which was proved by X-ray crystal structure analysis (Fig. 7) [22b] was obtained in the reaction of the chloro ester 1-Me with 2-aminoethanethiol (156) using K2CO3 or EtgN as a base in 43 and 20% yield, respectively (Scheme 49) [22b, 26]. In the latter case, the secondary amino group in the primary tetrahydrothiazine product 157 underwent Michael addition to a second molecule of 1-Me to give 2-[r-(spirocyclopropanetetrahydrothiazinyl) cyclopropyl]-2-chloroacetate 158 (14% yield). When KOH in the presence of di-benzo-18-crown-6 was employed, however, the seven-membered heterocycles 155 (42%) and 159 (48%) were obtained upon reaction of 1-Me with 1,3-pro-panedithiol and 2-aminoethanethiol, respectively (Scheme 49) [26]. [Pg.192]

An S-acetylated 2-aminothiol was reacted with 2-chloroacyl chlorides (Equation 85) <1989JPS937>. The reactions of 2-aminoethanethiol with 2,3-butanedione <1998JFA2278>, alkynyl cyanide 279 <1993TL5681>, and cyclic hemiacylal 281 <1992FI(34)2131> are shown in Scheme 59. Mechanisms for the formation of products 277, 278, and 280 were suggested, but not however for the unexpected product from 281. [Pg.656]

Both 2-aminoethanethiol and 2-aminothiophenol can be reacted with the same chloroenamine 282 to give 121 and 122 (Scheme 60) <2005RJ0508>. [Pg.657]

Both 2-aminoethanethiol and 2-aminothiophenol were reacted with epoxyesters to give thiazin-3-ones (Scheme 71) <1999J(P1)149>. [Pg.662]

Published routes to pyrazino[2,3-3][l,4]thiazines, as reviewed in CHEC-II(1996) <1996CHEC-II(7)737>, involved the reaction of a 3-aminopyrazine-2-thiol with a biselectrophile and of a 3-chloropyrazin-2-amine with thioglycolate. In more recent work, the system is formed by condensation of a dichloropyrazine with a 2-aminothiophenol (Equation 182) <2002CPB922>. The same approach, using either 2-aminothiophenol or 2-aminoethanethiol, has been used to form oxadiazole-fused systems (Scheme 100) <1997CHE1352>. In studies toward the synthesis of ER-49890 151, benzannulated pyrazino[2,3-/ ][l,4]thiazines have also been accessed by an indirect sequence (Scheme 101)<2005H(65)403>. [Pg.1072]

The condensation of 2-aminoethanethiol with a l,2-bis(electrophile) to give a mixture of perhydro-l,4-thiazino[3, 2-3][l,4]thiazine and 2,2 -bis(thiazolidine) was included in CHEC-II(1996) <1996CHEC-II(7)737>. The direct preparation of this target from glyoxal was not achieved, but this method has been used successfully for the preparation of 166 (Equation 192). [Pg.1079]

Reactions of this type provide major routes to both the monocyclic system and to 1,5-benzothiazepines. In some cases the reactions are single-stage processes but in many cases the intermediate produced by the primary formation of the S—C bond can be isolated. Thus 2-aminoethanethiol reacts with a,/3-unsaturated or j3-halogeno ketones to give (408). Similarly reaction with a,/3-unsaturated acids, esters or acid chlorides and with 3-halogenopropionyl halides gives the 5-oxo derivative (409). 2-Aminoethanethiol also reacts with activated 2-chlorobenzophenones to give 1,4-benzothiazepines. [Pg.634]

The superoxo-containing species [(NC)6Co(/u.-02)Co(CN5]5 can be reduced with thiols such as 2-aminoethanethiol or L-cysteine (175), and the reduction reaction is catalyzed by copper(II) ions in aqueous solution. When copper(II) is present, the role of the thiol is to reduce cop-per(II) to copper(I), which then reacts with the superoxo species through an inner-sphere mechanism. Conversely, when the superoxo complex [(H3N)5Co(/x-02)Co(NH3)5]5+ is reduced with thiol (176), the reaction follows an outer-sphere mechanism, as would be expected. Ascorbic acid also reduces both complexes (177), but only the reduction of the cyano-containing complex exhibits copper(II) catalysis. [Pg.313]

Table 40 Some Oxovanadium(IY) Complexes Derived from Salicylaldehyde or Substituted Salicylalde-hyde with 2-Aminoethanethiol (83), 3-Aminothiophenol (84) or 2-Aminothiophenol (86) (on reflux)... Table 40 Some Oxovanadium(IY) Complexes Derived from Salicylaldehyde or Substituted Salicylalde-hyde with 2-Aminoethanethiol (83), 3-Aminothiophenol (84) or 2-Aminothiophenol (86) (on reflux)...
Aminoethanethiol reacts with ot, 3-unsaturated or (3-halo ketones to give (355). Similarly, reaction with a, (3-unsaturated acids, esters or acid chlorides, and with 3-halopropionyl halides, yields 5-oxo derivatives such as (356). Thioglycollic acid (HSCH2C02H) with 3-bromopropylamine gives (357). [Pg.586]

In lieu of preparing and handling large amount of ethylene sulfide, ethyl 2-mercaptoethylcarbonate (XII) has been employed uiib advantage in the mercaptoethylation of primary and secondary amines.8 Introduction of this carbonate into a refluxing solution ol amine in toluene promotes its decomposition to ethylene suJfi.K carbon dioxide and ethanol. The ethylene sulfide react with the amine to give the 2-aminoethanethiol (Eq, 47). [Pg.311]

Complexes with 2-(2-mercaptoethyl)pyridine are strictly similar to those obtained with 2-aminoethanethiol and were prepared in MeOH/H20 solution made alkaline with NH3 by reacting the ligand with NiS04 hydrate.2421... [Pg.212]

Likewise, 2-(2-aminoethylsulfanyl)benzenesulfonamidccan be obtained from 2-fluorobenzene-sulfonamide (0.85 mol) and 2-aminoethanethiol (1.06 mol) with potassium carbonate (2.13 mol) in 1-methylpyrrolidin-2-one (530mL) (2 h at 140 C) yield 68.5%. mp 86-87 C (SFI more reactive than NH2).7... [Pg.428]


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2- Aminoethanethiole hydrochloride

Aminoethanethiols

Aminoethanethiols

Diisopropyl aminoethanethiol

From 2-Aminoethanethiol and Related Compounds

Nickel complexes 2- aminoethanethiol

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