Amino sugars chitobiose

Considerable attention continues to be given to disaccharides containing amino sugars. Compound 69, which comprises chitobiose linked to dolichol via an a-1-pyrophosphate bridge, has been prepared chemically as a substrate for enzymic glycosylation of peptides, and the chitobiose component was found to be transferable to a peptide.In related work, compounds 70 and 71 were prepared starting from chitobiose octacetate, and the former acts as an efficient acceptor for mannosyl transferases. The anhydrochitobiose... 

Comparisons have been made of the 3D structure of hevein in solution with the structures reported for other hevein domains, including WGA and hevein itself in the solid state.Despite differences in the number and nature of several amino acid residues, the polypeptide conformation has also been compared with the NMR-derived structure of a smaller antifungal peptide (30 amino acids) termed Ac-AMP2. The interactions just described have also been observed in the crystal structures of WGA-chitobiose and WGA-sialyllactose (see later). In all cases, the obtained conformations and intermolecular protein-sugar interactions are indeed similar (see later), regardless of the experimental method used to determine the 3D structure. 

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