3- Amino-p-cresol

Wang resin was purchased from Advanced ChemTech (1% DVB, 0.70mmol/g substitution, 100-200 mash, Cat. SA5009). Anhydrous tetrahydrofuran (THF), A/A-dimcthyl-formamide (DMF), methanol, dichloromethane, pyridine, 1,1 -carbonyldiimidazole (CDI), piperazine, homopiperazine, trans-1,4-diaminocyclohexane, 4-(dimethylamino)pyridine (DMAP), succinic anhydride, diglycolic anhydride, 3-methyl-glutaric anhydride, 2-aminophenol, 2-amino-p-cresol, 2-amino-4-tert-butyl phenol, /V-methylmorpholine (NMM), triphenylphosphine, diethyl azodicarboxylate (DEAD), and trifluoroacetic acid (TFA) were purchased from Aldrich Chemical Company, Inc. and used without further purification. PyBOP was purchased from Novabiochem. 

Amino-p-cresol (OH = l) 68 A solution of 2-nitro-p-cresol (10 g) in water (200 ml) and concentrated ammonia solution (50 ml) is added slowly to one of sodium dithionite (75 g) in water (300 ml). A white, crystalline but flocculent precipitate appears in 5 min, the red color of the solution changing to pale yellow. The whole mixture (unfiltered) is extracted with ether. The extract is dried, treated with charcoal, and evaporated, yielding yellowish-brown crystals (6.8 g, 81%), m.p. 134-135°. 

Amino-4-methyl phenol CAS 95-84-1 EINECS/ELINCS 202-457-3 Synonyms 2-Amino-p-cresol 6-Hydrxy-m-toluidine Phenol, 2-amino-4-methyl-Empincal C7H9NO... 

Pyridinecarboxaldehyde, (PCA), aminophenols, (AP), including 2-aniinophenol, 2-amino-m-cresol, 2-amino-p-cresol, 2-amino-4-tert-butylphenol, 2-amino-chlorophenol, 2-aminophenylphenol, were purchased from Aldrich (Milwaukee, WI) and used without further purification. 

H2N. C6H(CHJ)(NOa)1OH. Yel ndls (from w). Can be prepd by treating 3,5-dini tro-2-azido- 1-methyl-benzene with coned HaS04 Note The identity of this compd was not definitely established. It might be 2,6-DinitrO 3-amino-p Cresol Refs l)Beil 13, 614 2)P.Drost, Ann... 

Dinitro-3-amino-p.cresol 3,5-Dinitro-2-amino-4-hydroxy- elvme or 3,5-Dinltro-2-amine-4-hydroxy-1-methy. benzon . 

SYNS m-AMINO-p-CRESOL, METHYL ESTER 3-AMINO-p-CRESOL METHYL ESTER l-AMINO-2-METHOXY-5-METHYLBENZENE 3-AMINO-4-METHOXYTOLUENE 2-AMINO-4-METHYLANISOLE AZOIC RED 36 C.I, AZOIC RED 83 CRESIDINE p-CRESIDINE KRESIDIN KREZIDINE 2-METHOXY-5-METHYLANILINE 2-METHOXY-5-METHYL-BENZENAMINE (9CI) 4-METHOXY-m-TOLUIDINE 4-METHYL-2-AMINOANISOLE NCI-C02982... 

Conversion of Phenols to Amines. Aniline and some diphenylamine are formed when phenol and NHs solution are heated under pressure in the presence of FeCh, Al(OH)s, or Fe(OH)j. When NH and phenol or ortho-or para-cresols are reacted in the vapor phase over an AljO catalyst, yields of up to 88 per cent of the corresponding amines are obtained. However, these amines are customarily obtained by reducing the parent nitro compound, except in cases where it is difficult to obtain the required nitro isomer. For example, it is considered that the amination of symr xylenol is the best method of preparing sym-xylidine (l-amino-3,5-di-methylbenzene). When sym-xylenol is heated under pressure to 320 C with ammonium chloride, about equal amounts of sj/m-xylidine and sym-dixylylamine (5-imino-bis-l,3-dimethylbenzene) are formed. The ortho-and para-nitrophenols and nitrocresols can be aminat more readily. 2-Nitro-p-cresol [OH(l), N02(2), CHj(4)] and o-nitrophenol have been aminated in aqueous ammonia containing ammonium salts of weak acids to inhibit decomposition. Phosphoric, boric, carbonic, and formic acids were used. In one case it is claimed that 55-65 per cent yields of 2-nitro-p-toluidine (MNPT of commerce) were obtained when 2-nitro-p-cresol, 28 per cent aqueous NHj, and monoammonium phosphate, 1 11.5 0.2 molar ratio, were heated under pressure for 10 hr at 140-150°C and then 5 hr at about 160 C. Earlier workers, employing somewhat similar conditions, claimed excellent yields of MNPT when 1 mole of ammonium formate was used per mole of 2-nitro-p-cresol. ... 

CAS 120-71-8 EINECS/ELINCS 204-419-1 Synonyms m-Amino-p-cresol, methyl ester 3-Amino-p-cresol, methyl ether 1-Amino-2-methoxy-5-methylbenzene 3-Amino-4-methoxytoluene 2-Amino-4-methylanisole... 

UVA 2-hydroxy-4-octyloxybenzophenone 2-hydroxy-4-methoxybenzophenone 2-(2H-benzotriazol-2-yl)-p-cresol 2-(2H-benzotriazole-2-yl)-4,6-di-tert-pentylphenol 2-(2H-benzotriazole-2-yl)-4-(1,1,3,3-tetraethylbutyl)phenol 2,4-di-tert-butyl-6-(5-chloro-2H-benzotriazole-2-yl)-phenol 2-[4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl]-5-(octyloxy) phenol ethyl-2-cyano-3,3-diphenylacrylate HAS 1,3,5-tri-azine-2,4,6-triamine, N,N [1,2-ethane-diyl-bis[[[4,6-bis[butyl-(1,2,6,6-pentamethyl-4-piperidinyl)amino]-1,3,5-triazine-2-yl] imino]-3,1 -propanediyi] bis[N ,N -dibutyl-N ,N -bis(1,2,2,6,6-pentamethyl-4-piperidinyl)- bis(2,2,6,6-tetramethyl-4-piper-idyl) sebacate 2,2,6,6-tetramethyl-4-piperidinyl stearate N,N -bisformyl-N,N -bis-(2,2,6,6-tetramethyl-4-piperidinyl)-hexamethylendiamine alkenes, C20-24-.alpha.-, polymers with maleic anhydride, reaction products with 2,2,6,6-tet-ramethyl-4-piperidinamine 1,6-hexanediamine, N, N -bis(2,2,6,6-tetramethyl-4-piperidinyl)-, polymers with 2,4-di-ohloro-6-(4-morpholinyl)-1,3,5-triazine 1,6-hexanediamine, N,N -bis(2,2,6,6-tetramethyl-4-piperidinyl)-, polymers with morpholine-2,4,6-trichloro-1,3,5-triazine reaction products, methylated Phenolic antioxidants ethylene-bis(oxyethylene)-bis(3-(5-tert-butyl-4-hydroxy-m-tolyl)-propionate) 2,6,-di-tert-butyl-4-(4,6-bis(octylthio)-1,3,5,-triazine-2-ylamino) phenol pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate) 2-(1,1 -dimethylethyl)-6-[[3-(1,1 -dimethylethyl)-2-hydroxy-5-methylphenyl] methyl-4-methylphenyl acrylate isotridecyl-3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate 2,2 -ethylidenebis (4,6-di-tert-butylphenol) 2,2 -methylenebis(4-ethyl-6-tertbutylphenol) 3,5-bis(1,1-dimethyethyl)-4-hydroxy-benzenepropanoic acid, C13-15 alkyl esters phenol, 4-methyl-, reaction products with dicyclopen-tadiene and isobutene Phosphite trinonylphenol phosphite isodecyl diphenyl phosphite... 

Stabilizers UVA 2,4-dihydroxybenzophenone 2-(2H-benzotriazol-2-yl)-p-cresol 2-(2H-benzotriazole-2-yl)-4,6-di-tert-pentylphenol 2-(2H-benzotriazole-2-yl)-4-(1,1,3,3-tetraethylbutyl)phe-nol HAS 1,3,5-triazine-2,4,6-triamine, N,N [1,2-ethane-diyl-bis[[[4,6-bis[butyl(1,2,6,6-pentamethyl-4-piperidinyl) amino]-1,3,5-triazine-2-yl]imino]-3,1 -propanediyl]bis[N ,N -dibutyl-N ,N -bis(1,2,2,6,6-pentamethyl-4-piperidinyl)- bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate 2,2,6,6-tetra-methyl-4-piperidinyl stearate ... 

The use of a zirconium catalyst derived from BINOL (Lj in Scheme 11.4 10 mol%) as promoter for the three-component Mannich-type reaction of 5-hexynal, 2-amino-m-cresol and the ketene silyl ketal derived from phenyl propionate provided an efficient and simple protocol for the preparation of a new p-amino acid derivative (>99% yield, 82% de, 99% ee), which was essential for the total synthesis of onchidin, a cytotoxic, C2-symmetric, cyclic decadepsipeptide isolated from a marine mollusk [16]. 

Dinitro-p-cresol 2,4,6-rTrinitroaniline (Picramide) sym-Trinitromesytylene (1,3,5-Triraethyl-2,4,6-trinitrobenzene) 2,4,6-Trinitroresorcinol (Styphnic Acid) 2-Amino-... 

Acid catalyzed Sehiff base condensation of 2,6-diformyl-p-cresol and TETA (triethylenetetraamine) with Pr3+ as the template cation (in methanol) afforded a 1 1 product containing a tetraclinching alcohol (Eq. 9b, Table 9) [132]. One of the carbonyl groups was acetylated under mild acidic conditions. The 10-coord-ination around Pr3 + achieved by one aryloxide site, one imine and three amino nitrogen, two bidentate nitrate anions and one molecule of methanol is best described as a bicapped square antiprism. 

Bis [[2-(3,5-dimethyl-l-pyrazolyl)ethyl][2-(2-pyridyl)ethyl]amino]methyl -p-cresol... 

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