5- Amino-4,5-dimethyl-4-hydroxy

Acetyl-phenyl- 635 4-Amino-3,5-dimethyl-phenyl- 102 2-Amino-4-hydroxy-phenyl- 692 4-Amino-phenyl- 685 4-Benzylamino-phenyl- 102 2,4-Dinitro-phenyl- 692 4-(2-Hydroxy-benzylamino)-phenyl- 102 2-(2-Methyl-butanoyl)-phenyl- 635 4-Methoxy-2,6-dimethyl-phenyl-102 (Nitro-phenyl)- 635 2-Nitro-phenyl- 680, 692 4-Nitro-phenyl- 685... 

Dimethoxycarbonyl- 669 Dimethylamino- 360, 453 Dimethylaminocarbonyl- 234f. trans -2-Dimethyl amino- 1-hydroxy-... 

The CES family of proteins is characterized by the ability to hydrolyze a wide variety of aromatic and aliphatic substrates containing ester, thioester, and amide bonds (Heymann 1980, 1982). Cauxin is a member of the CES family, and is secreted from the proximal straight tubular cells into the urine in a species-, sex-, and age-dependent manner. Therefore, we postulated that cauxin was involved in an enzymatic reaction in cat urine and the products made by the reaction should vary with species, sex, and age. Based on this hypothesis, we searched for physiological substrates and products of cauxin in cat urine and identified 2-amino-7-hydroxy-5,5-dimethyl-4-thiaheptanoic acid, also known as felinine. 

Hendriks, W.H., Woolhouse, A.D., Tarttelin, M.F. and Moughan, P.J. (1995a) Synthesis of felinine, 2-amino-7-hydroxy-5,5-dimethyl-4-thiahep-tanoic acid. Bioorg. Chem. 23, 89-100. 

Agilent ChemStation software, 29-31, 33 Alkylquinaxolines, in Phodopus roborovskii, 19 Allomones, 13 2-Aminoacetophenon, 155 2-Amino-7-hydroxy-5,5-dimethyl-4-thiaheptanoic acid, see Felinine Amniotic fluid, odour of, 194 Amphetamine, 266... 

Trypan Blue 3,3 -[(3,3 -Dimethyl[ 1,1 -biphenyl] -4,4 -diyl)bis(azo)]bis[5-amino-4-hydroxy-2,7-naphtalenedisulphonicacid]tetrasodium salt... 

In waBriger Losung kann l,l-Dimethyl-2-hydroxy-guanidin ebenfalls direkt zu 3-Dimethyl-amino-5-hydroxy-l,2,4-oxadiazol (10% Schmp. 193-195°) umgesetzt werden102 ... 

Durch Erhitzen von aromatischen Sulfonsaure-(hydroxy-aniliden) in verdunnter Kalilauge oder mit Kaliumhydroxid in Dimethyl-sulfoxid erhalt man Amino-hydroxy-biphe-nyle z. B. 2-Amino-4-hydroxy-4 -nitro-biphenyl (80%)3 ... 

Die Anwendung ahnlicher Bedingnngen auf 2,2-Dimethyl-oxetan und 2-Ethenyl-oxetan fiihrt zu 2-Amino-4-hydroxy-2-methyl-kutan bzw. 3-Amino-5-hydroxy-l-penten5 ... 

Applications of the Conrad-Limpach reaction to the synthesis of 1-hydroxy-4,7-phenanthrolines or, more correctly, l-oxo-l,4-dihydro-4,7-phenanthrolines, from p-phenylenediamine or 6-aminoquinolines continue to be reported. l,10-Dihydroxy-3,8-dimethyl-4,7-phenanthroline has again been prepared from p-phenylenediamine,234 hot diphenyl ether being used to effect the cyclization. Other examples include the new or improved preparations of l-hydroxy-3-methyl-, 10-amino-l-hydroxy-3-methyl-,232 2-(y-chlorocrotonyl)- l,10-dihydroxy-3,8-dimethyl-, and 2,9-bis (y- chlorocrotonyl)-1,10- dihydroxy - 3,8 - dimethyl - 4,7 - phenanthro-lines.235 Compounds prepared in this way have been patented as antiasthmatic agents.178 A closely related synthesis employing poly-phosphoric acid as cyclizing agent has yielded l-hydroxy-3-phenyl-4,7-phenanthroline.236... 

N-Methylated and N,0-dimethylated y-amino-p-hydroxy acids are present in natural compounds of marine origin, e.g. hapalosin1 and dolastatin 10J9 ... 

In basic chemicals, nitrile hydratase and nitrilases have been most successful. Acrylamide from acrylonitrile is now a 30 000 tpy process. In a product tree starting from the addition of HCN to butadiene, nicotinamide (from 3-cyanopyridine, for animal feed), 5-cyanovaleramide (from adiponitrile, for herbicide precursor), and 4-cyanopentanoic acid (from 2-methylglutaronitrile, for l,5-dimethyl-2-piperidone solvent) have been developed. Both the enantioselective addition of HCN to aldehydes with oxynitrilase and the dihydroxylation of substituted benzenes with toluene (or naphthalene) dioxygenase, which are far superior to chemical routes, open up pathways to amino and hydroxy acids, amino alcohols, and diamines in the first case and alkaloids, prostaglandins, and carbohydrate derivatives in the second case. 

Amino-3-hydroxy-5-t-butyloxycarbonylamino-l,6-diphenylhexanesuccinate (111.9 g, 0.25 mol) was charged to a 2-L 3-necked flask with mechanical stirring. NaHC03 (106 g, 1.26 mol), 600 ml H20 and 600 ml EtOAc were added and stirred until solids were dissolved (15 min). A solution of the 2,6-dimethyl-phenoxyacetyl chloride and EtOAc (100 ml) was added. After 30 min starting materials were consumed (HPLC analysis) and the layers were separated. The aqueous layer was extracted with EtOAc, the organic layers were combined and washed with 200 ml of 1 M NaOH, 200 ml of 10% HCI, 200 ml of brine, dried over MgS04, filtered and concentrated to provide (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-(t-butyloxycarbonylamino)-l,6-diphenylhexane as a white solid. 

Analog erhalt man aus 3-Dimethylamino-propansaure in 57%iger Ausbeute 3-Dimethyl-amino- 1 - hydroxy-pro pan-1,1 -diphosphonsaure . 

Amino-2,3-dimethyl-3-hydroxy-E21b, 1770 (COOR - COOH) 2-Amino-3-hydroxy-2-methyl- -methylester E2Ib, 1770 (aus einetn 2,5-H2-Pyrazin-Der.) 2-Amino-2-hydroxymethyI-3-methyl-Vl/la, 2, 1331 Carbamidsaure... 

Methylation of 2-amino-3-hydroxypyrazine (62) with methyl iodide and sodium methoxide afforded 3-amino-l-methyl-2-oxo-1,2-dihydropyrazine (63), and when an excess of methyl iodide was used, a mixture of compound (63) and its methio-dide (64) was isolated. Reaction with dimethyl sulfate and alkaU gave compound (63) and l,4-dimethyl-2,3-dioxo-l,2,3,4-tetrahydropyrazine (66) the latter was presumed to be formed by hydrolysis of an intermediate quaternary salt since it was also obtained by treatment of the methiodide (64) with aqueous sodium hydroxide. Reaction of 2-amino-3-hydroxypyrazine with ethereal diazomethane produced a mixture of N- and 0-methyl derivatives, (63) and 2-amino-3-methoxy-pyrazine (65). With methyl toluene-p-sulfonate the quaternary salt 2-amino-3-hydroxy-1-methylpyrazinium toluenesulfonate (67) was obtained on alkaline hydrolysis it gave 3-hydroxy-l-methyl-2-oxo-l,2-dihydropyrazine (68) (832). Pulcherriminic acid with diazomethane gave a dimethyl derivative (99). 

Reduction of 2-hydroxy-3,6-dimethyl-5-phenylazopyrazine (8) with sodium hydrosulfite (dithionite) gave 2-amino-5-hydroxy-3,6-dimethylpyrazine (872), and vigorous reduction of the disodium salt of 2-(p-sulfophenylazo)-3-methyI-5-hydroxypyrazine with stannous chloride and hydrochloric acid gave 2-amino-5-hydroxy-3-methylpyrazine (434). 2-Hydroxy-5,6-diphenyl-3-phenylazopyrazine in methanol was reduced with hydrogen over Raney nickel to 2-amino-3-hydroxy-5,6-... 

A 2-amino-5-substituted-pyrazine refluxed with p-toluenethiol, 2-methoxy-ethanol, and 2-amino-6-formyl-4-hydroxypteridine followed by heating with acetic anhydride gave the 2-amino-4-hydroxy-6-[A -(5 -substituted-pyrazin-2 -yl)-acetamidomethyl]pteridine (34) (1244). 2-Amino-5-phenylpyrazine with isobutyral-dehyde in ether at room temperature gave 2-(3-isopropyl-6, 6-dimethyl-5, 6-dihydro-l, 2, 4 -trioxin-5 -yl)aniino-5-phenylpyrazine (35) (1245). 

Dicyanopyrazine with sodium methoxide in methanol with ammonia at reflux gave 5,7-diimino-6//-pyrrolo[3,4-i)]pyrazine (65) (1442) and 2,3-dicyano-5,6-dimethyl(and 5,6-diphenyl)pyrazine with hydrazine by the procedure of Patel and Castle (1339) gave 2,3-dimethyl(and 2,3-diphenyl)-5,8-diaminopyrazino[2,3-rfJ-pyridazine(s) (66) (1435). Fusion of 2-chloro-3-cyano-5,6-diphenylpyrazine with urea and thiourea was reported to give 4-amino-2-hydroxy(and mercapto)-6,7-diphenylpteridine (848). 

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