Oximes amines

As discussed in Chapter 6, nitro compounds are converted into amines, oximes, or carbonyl compounds. They serve as usefid starting materials for the preparation of various heterocyclic compounds. Especially, five-membered nitrogen heterocycles, such as pyrroles, indoles, ind pyrrolidines, are frequently prepared from nitro compounds. Syntheses of heterocyclic compounds using nitro compounds are described partially in Chapters 4, 6 and 9. This chapter focuses on synthesis of hetero-aromadcs fmainly pyrroles ind indolesi ind saturated nitrogen heterocycles such as pyrrolidines ind their derivadves. 

Oxidation of Primary Amines, Oximes, Azides, Isocyanates, or Nitroso Compounds to Nitro Compounds... 

Oxidation of primary amines, oximes, azides, isocyanates, or nitroso... 

The inability of amines to deprotonate upon coordination, and thus to compensate the charge of the MOs+ core, can be overcome by combination with other types of donors-including N-donor groups-in the ligand, as has already been discussed above for oxocyclam. A prominent example is provided by technetium complexes of tetradentate amine oxime ligands. 

Fig. 9. PnAO and HMPAO (acro-nyms used in nuclear medicine) Pn = propylene, AO = amine oxime ...

Mah, G., Reilly, R. M., Wong, G. L. and Houle, S. A comparison of three methods to determine the radiochemical purity of 99mTc-hexamethylpropylene amine oxime (99mTc-HMPAO). Nucl. Med. Commun. 10 733-740,1989. 

Hence in all experiments with Grignard reagents moisture must he completely excluded. Alcohols, phenols, carboxylic acids, primary and secondary amines, oximes, acetylene, etc., react in the same way as water. 

Weak donor acceptor Alcohol, organic acid, phenol, primary and secondary amines, oxime, nitro and nitrile compounds having hydrogen at a-position, hydrazine, HF, and HCN... 

Class 2 Molecules with active H-atoms and electronegative atoms with pairs of free electrons (0, N, F) Alcohols, acids, phenols, prim, and sek. amines, oximes, nitro compoimds and nitriles with a-H-atoms like hydrazine, NH3, HF, HCN, etc. 

Substituted hydroxylamines 1-5 (R = R = H) and their A-mono- or A,A-disub-stituted derivatives 1-5 have been used extensively for electrophilic amination of both carbanions and enolates since the first report in 1938 on the use of 0-methylhydroxylamine 1 (R = Me) for conversion of Grignard reagents to primary amines. Oximes 7 (Z = H) have found limited applicability as amination reagents for carbon nucleophiles and then-use was first reported in 1907. Ketone 0-sulfonyloximes 7 (Z = SO2R) have recently been developed. 

DA, dopamine DD, depressive disorders (major depression and/or dysthymia) DZ, dizygotic twins 5-HT, serotonin p-CIT, iodine-123-labeled 2p-carbomethoxy-3p(iodophenyl) tropane MDD,major depressive disorder MRI, magnetic resonance imaging MZ, monozygotic twins NC, normal controls PC, psychiatric controls PTSD post-traumatic stress disorder rCBF, regional cerebral blood flow SPECT, single photon emission computerized tomography Tc HMPAO, technetium-99m hexamethylpropylene amine oxime. 

Tutus, A., Kibar, M., Sofuoglu, S., Basturk, M., and Gonul, A.S. (1998) A technetium-99m hexamethylpropylene amine oxime brain single-photon emission tomography study in adolescent patients with major depressive disorder. Eur J Nucl Med 25 601— 606. 

Alcohols Carboxylic acids Phenols Primary and secondary amines Oximes Nitro compounds (with a-H atoms) Nitriles (with a-H atoms) Polyhydroxyalcohols Amino alcohols Hydroxy acids Polyprotic acids Polyphenols... 

A review article covering the synthesis, characterization and redox properties of imine-amine-oxime ligands has recently appeared.3030... 

In an alternate procedure, the last step is carried out in acetonitrile using the same quantities. During the addition of the diamine, the solution is maintained at 5°C, allowed to rise slowly to room temperature for about 15 min, and then warmed to about 75°C for one-half hour. ( Caution. The temperature must be monitored closely since the reaction is strongly exothermic.) The relatively pure amine oxime hydrochloride (PnAO 2HC1) is collected on a filter and washed with 50-mL portions of acetonitrile and dried in air. 

Hydroxyl- amine Oximation Elemental analysis, photometric, titration Sensitivity depends highly [83,89] on detection mode ... 

Schlemper and co-workers have reported the X-ray structures of the products of the reaction of RhCl3 3H20 with a series of similar amine oximes (A-O 60). The reaction product is intriguingly dependent on the length of the hydrocarbon chain linking the two amine oxime moieties, and... 

Isothiocyanate N-halo N-Hydroxy amine (oximes/oxime ether) N-oxide... 

Diethyl-4-methyl-2-oxo-2,5-dihydro- -3-oxid E14b, 1432 (Amin-oxim/COCl2)... 

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