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Amide Linkers

Structure-activity studies of 5,6,7,8-tetrahdyro-5,5,8,8-tetramethyl-2-quinoxaline derivatives necessitated the preparation of thiophene-containing compound 17. Stetter conditions using thiazolium salt 20 as catalyst resulted in the preparation of 1,4-diketone 21 from 18 and 19. Condensation of 21 with phosphorus pentasulfide followed by saponification resulted in 17. In this fashion, the authors replaced the amide linker of parent compound 22 with the rigid thiophene moiety. [Pg.211]

The solid-phase synthesis of the 2(lff)-pyrazinone scaffold is based on a Strecker reaction of commercially available Wang amide linker with appropriate aldehyde and tetramethylsilyl (TMS) cyanide, followed by cyclization of a-aminonitrile with oxalyl chloride resulting in the resin linked pyrazinones. This approach allows a wide diversity at the C-6-position of pyrazinone scaffold (Scheme 35, Table 1). As it has been shown for the solution phase, the sensitive imidoyl chloride moiety can easily undergo an addition/elimination reaction with in situ-generated sodium methoxide affording the resin-linked... [Pg.292]

Jensen KJ, Alsina J, Songster MF, Vagner J, Albericio F, Barany G. Backbone amide linker (BAL) strategy for solid-phase synthesis of C-terminal-modified and cyclic peptides. J Am Chem Soc 1998 120 5441— 5452. [Pg.222]

Brown EG, Nuss JM. Alkylation of Rink s amide linker on polystyrene resin a reductive amination approach to modified amine-linkers for the solid phase synthesis of /Y-substiuited amide derivatives. Tetrahedron Lett 1997 38 8457-8460. [Pg.222]

To 100 MicroTubes in 100 mL of DCM, the following were added sequentially 4.96 g (9.2 mmol) Rink amide linker (note 6), 3.20mL (18.4mmol) DIEA, and6.9g (18.4mmol) HATU (note 7). The reaction mixture was shaken at room temperature for 48 h. After the supernatant was removed by aspiration, the MicroTubes were washed sequentially with DMF, MeOH, and DCM for three cycles. The MicroTubes were dried under vacuum for 5 h after a final washing with ethyl ether. [Pg.18]

Our library synthesis was carried out with a set of 27 tube-shaped solid phase synthesis support, called MicroTubes. These supports are prepared by radiation grafting of polystyrene ( — 350 pmol) onto polypropylene tubes, chemically functionalizing the polystyrene with aminomethyl groups to afford about 55 imol of amine per tube, inserting a reusable Rf ID tag into each tube, and heat-sealing the tube ends to prevent loss of the tag. The chemical conversion of all 36 aminomethyl tubes was carried out simultaneously using standard procedures with rink amide linker, each with —46 pmol of available amine per tube.1 2... [Pg.21]

Rink amide linker was purchased from Midwest Biotech. [Pg.22]

BACKBONE AMIDE LINKER (BAL) STRATEGY FOR SOLID-PHASE SYNTHESIS... [Pg.121]

H-donor for both the intramolecular hydrogen bond with the amide linker carbonyl the carboxylic acid group is deprotonated. [Pg.401]

A linker originally designed for solid-phase synthesis of peptides is the backbone amide linker (11) (BAL), this anchoring approach has now been extended to the combinatorial synthesis of diverse amide [31], hydroxamate [32], oligosaccharide [33] and heterocyclic small molecule libraries [34-36]. [Pg.139]

Silyl Acid Linker 4-[l-Hydroxy-2-(trimethylsilyl)ethyl]-benzoic acid Silyl Amide Linker 4-[(l-Amino)-2-(trimethylsilyl)ethyl]-phenoxyace-... [Pg.188]

Piperazine-2,5-diones can be symmetric or asymmetric. Symmetric DKPs are readily obtained by heating amino acid esters,1179-181 whereas asymmetric DKPs are obtained directly from the related dipeptides under basic or, more properly, acid catalysis, or by cyclocondensation of dipeptide esters.1182-185 As an alternative procedure hexafluoroacetone can be used to protect/activate the amino acid for the synthesis of symmetric DKPs or of the second amino acid residue for synthesis of the dipeptide ester and subsequent direct cyclocondensation to DKPs.1186 The use of active esters for the cyclocondensation is less appropriate since it may lead to epimerization when a chiral amino acid is involved as the carboxy component in the cyclization reaction. Resin-bound DKPs as scaffolds for further on-resin transformations are readily prepared using the backbone amide linker (BAL) approach, where the amino acid ester is attached to the BAL resin by its a-amino group and then acylated with a Fmoc-protected amino acid by the HATU procedure, N -deprotection leads to on-resin DKP formation1172 (see Section 6.8.3.2.2.3). [Pg.473]

PPACK-NAPAP hybrid ligand (thick lines) generated by CCLD starting from the functional groups of PPACK and NAPAP (thin lines). The amide linker connecting the piperidine in 3-position to the D-Phe was created by CCLD. [Pg.553]

The work by Armstrong was extended to include the room temperature resin capture of trisubstituted ethenes with a pendant boronate group.80 Modification of the amide linker above to a novel silyl-based one allowed for the traceless cleavage of superior analogues. [Pg.55]


See other pages where Amide Linkers is mentioned: [Pg.130]    [Pg.107]    [Pg.203]    [Pg.238]    [Pg.356]    [Pg.194]    [Pg.195]    [Pg.119]    [Pg.315]    [Pg.315]    [Pg.147]    [Pg.18]    [Pg.122]    [Pg.126]    [Pg.134]    [Pg.138]    [Pg.148]    [Pg.148]    [Pg.148]    [Pg.154]    [Pg.555]    [Pg.130]    [Pg.404]    [Pg.405]    [Pg.140]    [Pg.144]    [Pg.187]    [Pg.130]    [Pg.76]    [Pg.76]    [Pg.495]    [Pg.384]    [Pg.19]    [Pg.553]   
See also in sourсe #XX -- [ Pg.20 ]




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Amide-based linker

Amides linkers for

Amides safety-catch linkers

Backbone amide linker

Backbone amide linkers

Diketopiperazines via Backbone Amide Linker (BAL)

Ester-, Amide- and Carbamate-Based Linkers

Linker amide

Linker amide

Linkers for Amides and Ureas

Peptide amide linker resin

Rink amide linker

Sieber amide linker

Sieber amide linker amides

Solid-phase linkers Rink amide linker

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