Amide-Linked Ferrocene

At this point the reader may wish to look briefly at the preferred analytical methods for the quantitative determination of the ferrocene contents in the reported conjugates, a task of crucial importance for their structural characterization and, hence, meaningful involvement in biomedical evaluation studies. Microanalytical determination of the iron contents will permit a calculation of the mass% ferrocene in the polymer and, thus, the extent of ferrocenylation, the latter defined as the mole fraction of ferrocene incorporated and expressed as a percentage of maximally available anchoring sites. In the author s laboratory, microanalytical assaying of the 

Michael-type polyaddition process, possesses four secondary amine segments in die overall base recurring unit as shown, with the two subunits randomly distributed along die backbone. Treated with the active iV-succinimidyl ester in dimethylformamide solution, it converts to a conjugate which, in principle, may thus contain four ferrocenyl 

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A longer CS lifetime was also attained by attaching an electron donor (ferrocene, Fc) to a ZnP—Cgo dyad to give a triad (Fc—ZnP—Cgo) (43). Upon photoexcitation of the ZnP moiety, ET from ZnP to Ceo occurs within 230 ps, followed by hole transfer to Ec after 500 ps to produce the long-lived CS state (Scheme 4). The CS lifetime (630 ps) of Ec + —ZnP—Cgo is much longer than the lifetime (8 ps) of a similar triad linked by longer amide linkage (34). 

By using reaction between amines and carboxylic acid, Zhang and coworkers reported the preparation of ferrocene-based shell cross-linked (SCL) thermoresponsive hybrid micelles with antitumor efficacy. The SCL micelle consisting of a cross-linked thermoresponsive hybrid shell and a hydrophobic core domain was fabricated via a two-step process micellization of poly(Af-isopropylacrylamide-co-aminoethyl methacrylate)- -polymethyl methacrylate P(NIPAAm-co-AMA)- -PMMA in aqueous solution followed by cross-linking of the hydrophilic shell layer via the amidation reaction between the amine groups of AMA units and the carboxylic acid functions of l,r-ferrocenedicarboxylic acid. ... 

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