American Thyroid Association

H18. Hay, I.D., Bayer, M. F., Kaplan, M. M., Klee, G. G., Larson, P. R., and Spencer, C. A., American Thyroid Association assessment of current free thyroid hormone and thyrotropin measurements and guidelines for future clinical assays. Clin. Cliem. 37,2002-2008 (1991). 

Consensus Statement 2. American Thyroid Association statement on early maternal thyroidal insufficiency Recognition, clinical management and research directions. Thyroid 2005 15 77. 

Gharib H et al Consensus statement 1 Subclinical thyroid dysfunction A joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association and the Endocrine Society. Thyroid 2005 15 24. [PMID 15687817]... 

Ladenson D et al American Thyroid Association guidelines for the detection of thyroid dysfunction. Arch Int Med 2000 160 1573. [PMID 10847249]... 

Surks MI, Chopra IJ, Mariash CN, Nicoloff JT, Solomon DH. American Thyroid Association guidelines for use of laboratory tests in thyroid disorders. JAMA 1990 263(ll) 1529-32. 

Gorman CA, Becker DV, Greenspan FS, Levy RP, Oppenheimer JH, Rivlin RS, Robbins J, Vanderlaan WP. Breast cancer and thyroid therapy. Statement by the American Thyroid Association. JAMA 1977 237(14) 1459-60. 

As the laboratory assessment of thyroid disease has been refined through die wide-scale availability of improved techniques and commercial kits, some confusion in terminology has developed. Table 52-1 is a review of the nomenclature for tests of thyroid hormones and thyroid-related proteins in serum. Guidehnes for the classification of various thyroid tests have been further described in a special report of the American Thyroid Association. 

To distinguish immunometric TSH assays from less sensitive RIAs, descriptive terms such as "sensitive, highly sensitive, ultrasensitive, and supersensitive have been used, generating much confusion as to the exact meaning of these terms. In 1991, a Nomenclature Committee of the American Thyroid Association recommended that the functional detection limit of serum TSH assays be determined on the basis of low-end interassay precision characteristics. Further, the committee recommended that precision at the lower reporting limit should optimally be 10% to 15% and preferably <20%. At present, functional sensitivity is defined as the lowest concentration of TSH at which an interassay coefficient of variation of 20% can be achieved. This functional detection hmit encompasses both analytical and... 

Numerous methods have been developed for assessing the concentrations of FT4 and FT3 in serum. These methods include direct assays that currently serve as reference methods and indirect assays that are more widely available for general laboratory use. The following section describes the principles of these methods and offers some guidelines for their use. The theoretical basis, analytical validity, and clinical utility of these methods have been discussed. Special reports from the Nomenclature Committee of the American Thyroid Association, the National Academy of Clinical Biochemistry, and the NCCLS also review some of the issues and concerns regarding free thyroid hormone measurements. 

To improve the understanding of THBR tests from different laboratories, the Committee on Nomenclature of the American Thyroid Association has recommended that uptake results for individual patients be normalized to those of a control serum (or reference serum pool) obtained from euthyroid patients who have normal quantities of TBPs. The quotient of these results is proportional to the free fraction of T4 or T3 in serum and is properly known as the THBR ... 

Prom Hay ID, Bayer MP, Kaplan MK, et al American Thyroid Association Assessment of current free thyroid hormone and thyrotropin measurement and guidelines for future clinical assays. Clin Chem 199i 37 2002 8. 

LaFranchi S. American Academy of Pediatrics. American Thyroid Association. Newborn screening for congenital hypothyroidism Recommended guide-hnes. Thyroid 1993 3 257-63. 

Singer PA, Cooper DS, Levy EG, et al. Treatment guideUnes for patients with hyperthyroidism and hypothyroidism. Standards of Care Committee, American Thyroid Association. JAMA 1995 273 808-812. 

Willhauck, M.J.,SharifSamani,B.R.,Senekowitsch-Schmidtke,R., Goke, B., Motris, J.C. and Spitzweg, C. (2006). Annual Meeting of the American Thyroid Association. Phoenix, AZ. 

Pearce, E.N., Lazarus, J.H., Smythe, P.P. et al. (2007a). Abstract 275, 78th Annual Meeting of the American Thyroid Association [Thyroid Reference]. 

American Academy of Pediatrics American Thyroid Association (1993). Pediatrics 91, 1203—1209. 

American Thyroid Association Public Health Committee (2006). Thyroid 16, 949-951. 

The American Thyroid Association has investigated how North American thyroid-ologists assess and treat amiodarone-induced thyrotoxicosis and has compared the results with those of a survey using the same questionnaire previously carried out among European thyroidologists [40 ]. Most of the respondents (91% versus 68% in Europe) see under 10 new cases of amiodarone-induced thyrotoxicosis per year, which seems to be less common than amiodarone-induced hypothyroidism in North America (34% and 66% of amiodarone-induced thyroid dysfunction respectively, compared with 75% and 25% in Europe). When thyrotoxicosis is suspected in North America hormonal assessment is mostly based on measurements of serum-free T4 and TSH, while serum-free T3 determination is requested less often than... 

Dr. Becker, the American Thyroid Association recommended a level of 100 REM for intervention. The statement seems somewhat ambiguous to me, since if 100 REM represents a level that you do not want to reach, the radiation level to intervene must be set at a lower level. 

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