Amantadine adverse reaction

Adverse reactions of amantadine include gastrointestinal upset with nausea and vomiting, anorexia, asthenia (weakness, loss of strength), constipation, depression, visual disturbances, psychosis, urinary retention, and orthostatic hypotension. 

The most common serious adverse reactions to amantadine are orthostatic hypotension, depression, congestive heart failure, psychosis, urinary retention, convulsions, leukopenia, and neutropenia Less serious reactions include hallucinations, confusion, anxiety, anorexia, nausea, and constipation. Adverse reactions with selegiline include nausea, hallucinations, confusion, depression, loss of balance, and dizziness. 

Amantadine is used cautiously in patients with seizure disorders, hepatic disease, psychosis, cardiac disease, and renal disease The antihistamines, pheno-thiazines, disopyramide, and alcohol increase the risk of adverse reactions when administered with amantadine... 

Stange KC, Little DW, Blatnik B (1991) Adverse reactions to amantadine prophylaxis of influenza in a retirement home. J Am Geriatr Soc 39 700-705... 

Livedo reticularis sometimes occurs in patients taking amantadine and usually clears within 1 month after the drug is withdrawn. Other dermatologic reactions have also been described. Peripheral edema, another well-recognized complication, is not accompanied by signs of cardiac, hepatic, or renal disease and responds to diuretics. Other adverse reactions to amantadine include headache, heart failure, postural hypotension, urinary retention, and gastrointestinal disturbances (eg, anorexia, nausea, constipation, and dry mouth). 

Adverse reactions include dizziness, nervousness, lightheadedness and insomnia. Drowsiness, hallucinations, delirium and coma may occur in patients with impaired renal function. Convulsions may be induced, and amantadine should be avoided in epileptic patients. 

Adverse reactions related to the administration of amantadine include ... 

Adverse effects Amantadine s side effects are mainly associated with the CNS. Minor neurologic symptoms include insomnia, dizziness, and ataxia. More serious side effects have been reported (for example, hallucinations, seizures). The drug should be employed cautiously in patients with psychiatric problems, cerebral atherosclerosis, renal impairment, or epilepsy. Rimantadine causes fewer CNS reactions since it does not efficiently cross the blood-brain barrier. Amantadine and rimantadine should be used with caution in pregnant and nursing mothers, because they have been found to be embryotoxic and teratogenic in rats. 

Multiple sclerosis Beta interferons, glatiramer acetate, glucocorticoids, antispasmodics, amantadine, stimulants, immunosuppressants Number of exacerbations, self-injection technique, injection site reactions, amount of spasticity, amount of fatigue, CBC and infections (immunosuppressants), medication-specific adverse effects... 

Memantine is chemically related to amantadine, and the manufacturer advises that concurrent use should be avoided or undertaken with caution because of the increased risk of adverse CNS-related drug reactions such as psychosis. Although there are no data, an increased risk is also predicted for ketamine and dextromethorphan, which are also NMDA antagonists. Avoidance of, or caution with, concurrent use is advised. 

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