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Glatiramer acetate

Glatiramer acetate (Copaxone) 20 mg SQ Daily Injection site reaction 90% Systemic reaction 15%... [Pg.437]

Pharmacology and Mechanism of Action The mechanism of action of glatiramer acetate is not fully known however, the following properties have been observed ... [Pg.438]

Efficacy Glatiramer acetate reduces relapses by 28% each year compared to placebo. Additionally, relapses occurred later compared to placebo (322 days versus 219 days).42... [Pg.438]

Glatiramer acetate EDSS, MSFC, neurologic history Every 3 months during the first year... [Pg.439]

Once diagnosed, work with the patient to select either a beta interferon or glatiramer acetate, considering ... [Pg.441]

Suhayl D-J. Glatiramer acetate (Copaxone) therapy for multiple sclerosis. Pharmacol Ther 2(X)3 98 245-55. [Pg.85]

Biological response modifiers glatiramer acetate interferon beta-la interferon beta-lb... [Pg.618]

Research Focus Improved method for preparing glatiramer acetate. [Pg.541]

Application similar synthetic methods have been reported in the patent literature for preparing glatiramer acetate. [Pg.541]

An alternative method for preparing glatiramer acetate was proposed by Ray et al. (3) and entailed ... [Pg.543]

Glatiramer Acetate is water soluble copolypeptide with molecular weight 15,000-25,000. [Pg.1766]

Copolymer is prepared by copolymerization of the N-carboxyanhydrides of tyrosine, alanine, lysine, and glutamic acid. The polymerisation was carried out at ambient temperature in anhydrous dioxane with diethylamine as initiator. Glatiramer Acetate have the ratio alanin glutamic acid lysine tyrosine = 1 6 4.54 2. [Pg.1766]

Glatiramer Acetate Mechanisms of Action in Multiple Sclerosis... [Pg.459]

Gordon PH, Doorish C, Montes J, Mosley RL, Diamorrd B, Macar -tliuT RB, Weimer LH, Kaufmaun P, Hays AP, Rowlarrd LP, Gen-delman HE, Przedborski S, Mitsumoto H (2006) Randomized conh olled phase II dial of glatiramer acetate hr ALS. Neur ology April 11, 2006 66(7) 1117—1119. En atum hr Neur ology. September 12, 2006 67(5) 920. [Pg.386]

Kipnis J, Schwartz M (2002) Dual acdon of glatiramer acetate (Cop-1 )in die deadnentof CNS autoimmune andneui odegeneradve disorders. Trends Mol Med 8 319—323. [Pg.386]

While no cure for MS is known, the FDA approves four immunotherapies for RR-MS. All shorten attacks and lengthen the time between attacks by 30% (Arnason, 1999a, 1999b). The therapies include variations of IFN (3 IFN (3-la, (Avonex and Rebif) and IFN (3-lb (Betaseron). The second type of immunotherapy, glatiramer acetate is a copolymer of four amino acids termed Copaxone. All approved therapies involve self... [Pg.592]

See other pages where Glatiramer acetate is mentioned: [Pg.436]    [Pg.438]    [Pg.589]    [Pg.619]    [Pg.644]    [Pg.591]    [Pg.621]    [Pg.70]    [Pg.359]    [Pg.561]    [Pg.187]    [Pg.541]    [Pg.542]    [Pg.1766]    [Pg.1766]    [Pg.1766]    [Pg.370]    [Pg.581]    [Pg.591]    [Pg.592]    [Pg.592]    [Pg.594]    [Pg.596]   
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