Alpha particle Antibody

Boron neutron capture therapy (BNCT) offers a potential method for localized destruction of tumor cells. The technology is based on the nuclear reaction between thermal neutrons and boron-10 (lOB) to yield alpha particles and lithium-7 nuclei. The destructive effect of this reaction is limited to a range of about the diameter of a single cell. In order for BNCT to be effective in cancer therapy, there must be selective delivery of an adequate concentration of lOB to tumors. Various types of antibodies as well as epidermal growth factor have been utilized to investigate receptor-mediated boron delivery however, in vivo studies have demonstrated that only a small percentage of the total... 

Wilbur, D. S., Hamlin, D. K., Chyan, M.-K., and Brechbiel, M. W. 2008. Streptavidin in antibody pretargeting. 5. Chemical modification of recombinant streptavidin for labeling with the alpha-particle-emitting radionuclides 213Bi and 211 At. Bioconjugate Chem., 19, 158-70. 

The ultrastructure of horse platelets is similar to that of human platelets (White et al. 1976). Features include a flattened discoid shape, a circumfiential band of microtubules, an open canalicular system, alpha granules, mitochondria, dense bodies, and glycogen particles. Compared to human platelets, horse dense bodies are analler and alpha granules are larger and stracturally more complex. The serotonin content of horse platelets is similar to that of human platelets. Horse platelet membrane proteins have been evaluated by polyacrylamide gel electrophoresis and glycoprotein llbllfe has been characterized and monoclonal antibodies have been produced (Lipscomb et al. 1995 Pintado et al. 1995). 

While lipoproteins are the products of many different genes, the major apolipoproteins share properties distinguishing them from most lipid-free and membrane-associated proteins. For example, apolipoproteins consist of a single polypeptide chain that has relatively little tertiary structure. Most apolipoproteins contain stretches of amphipathic alpha-helix, whose hydrophobic face can be turned to the lipid surface of the particle. The apolipoproteins are flexible, as is reflected in their unusually small free energy of unfolding. As these apolipoproteins expand and contract at the cell surface, different protein domains are exposed that are detectable with monoclonal antibodies. These properties reflect the role of apolipoproteins at the surface of lipoprotein particles whose size changes as they circulate. 

The adsorption and the chemical grafting of an antibody (anti-Alpha-foeto protein) onto thermosensitive magnetic latex particles is investigated as a function of pH ionic strength and temperature. The hydrophilic magnetic latexes bearing surface carboxylated groups are prepared... 

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