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Alpha-ketoglutarate, cyanide antidote

Hume AS, Mozigo JR, McIntyre B, et al. 1995. Antidotal efficacy of alpha-ketoglutaric acid and sodium thiosulfate in cyanide poisoning. Clinical Toxicol 33(6) 721-724. [Pg.254]

This compound, similar to glycer-aldehyde, pyruvate, and alpha-ketoglutarate, trapped cyanide to form cyanohydrin, thus rapidly reactivating the enzyme cytochrome oxidase and restoring CN-inhibited mitochondrial respiration. The authors have reported this antidote to be effective especially in cases of CN-carbon monoxide smoke inhalation. [Pg.318]

See other pages where Alpha-ketoglutarate, cyanide antidote is mentioned: [Pg.318]    [Pg.333]   
See also in sourсe #XX -- [ Pg.264 , Pg.265 ]



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