Allylamine antifungal agents

Terbinafine (Lamisil) is an allylamine antifungal agent that has been shown to be quite effective for the treatment of onychomycosis. Recommended oral dosing consists of 250 mg daily for 6 weeks for fingernail infections and 12 weeks for toenail infections. Recent reports of serious hepatic toxicity, including liver failure and death, have led to recommendations that patients receiving terbinafine for onychomycosis be monitored closely with periodic laboratory evaluations for possible hepatic dysfunction. 

G Petranyi, NS Ryder, A Stutz. Allylamine derivatives new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science 224 1239-1241,1984. 

Ganzinger U, Stutz A, Petranyi G, Stephen A. Allylamines topical and oral treatment of dermatomycoses with a new class of antifungal agents. Acta Dermatol Venereol Suppl (Stockh) 1986 121 155-60. 

Butenafine cream, 1%, contains the synthetic antifungal agent butenafine hydrochloride. Butenafine is a member of the class of antifungal compounds known as benzy-lamines, which are structurally related to the allylamines. Each gram of cream, 1%, contains 10 mg of butenafine... 

Fungal infections are among the most conunon causes of skin disease in the United States, and numerous effective topical and oral antifungal agents have been developed. Griseofulvin, topical and oral imidazoles, triazoles, and allylamines are the most effective agents available... 

Naftifine, a broad-spectrum antifungal agent, is a synthetic allylamine derivative that interferes with sterol biosynthesis by inhibiting the enzyme squalene 2,3-epoxidase. This inhibition of enzyme activity results in decreased amounts of sterols, especially ergosterol, and a corresponding accumulation of squalene in the cells. 

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