Allogenic tumours

A highly (1 6) branched (1 3)P-i>glu-can. Elaborated by the fungus Lentinus edodes (shiitake). Shows growth-inhibitory activity against certain allogenic tumours, particularly mouse sarcoma 180. Immunostimulant. Has been used in the treatment of malignant neoplasms and AIDS. Launched 1986. Powder. Sol. H2O, DMSO fairly sol. H2O poorly sol. EtOH, hexane. Forms nonelastic gel in aq. suspensions. 

CD8+ cytotoxic T-cells (CTL) bind to virally infected, tumour or allogenic cells and induce apoptosis in these target cells via a mechanism that is not prevented by inhibitors of protein and RNA synthesis (Duke et al., 1983 Ostergaard and Clark,... 

The allogeneic immune reactivity inhibits the growth of tumours originated in inbred strains of mice when transplanted in both High or Low responders. As we know that hybrids between the two lines and an inbred strain retain a substantial difference in antibody response, characteristic of High or Low line (see Table 5.11), we used such hybrids to study host resistance against leukaemia of AKR and DBA/2 mice. 

The safety and immunogenicity of the heat-treated zoster vaccine was assessed in a randomised, double-blind, placebo-controlled, multicenter study in a diverse population of immunocompromised adults (with solid tumour malignancy (STM), haematological malignancy (HM), HIV, or recipients of autologous haematopoietic stem-cell transplant (HCT) or allogeneic HCT). Importantly, this study showed that in all groups the heat-treated zoster vaccine... 

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