Allergy to aspirin

Before administering an NSAID, it is important for the nurse to determine if the patient has any history of allergy to aspirin or any otiier NSAID. The nurse determines if die patient has a history of gastrointestinal bleeding, hypertension, peptic ulceration, or impaired hepatic or renal function. If so, the nurse notifies the primary health care provider before administering an NSAID. 

I Contraindications Hypersensitivity to tablet components, such as tartrazine allergy to aspirin lactose intolerance Ml and thyrotoxicosis uncomplicated by hypothyroidism treatment of obesity... 

Thyrotoxicosis and myocardial infarction uncomplicated by hypothyroidism, hypersensitivity to any component (with tablets tartrazine, allergy to aspirin, lactose intolerance) treatment of obesity... 

Szczeklik A, Nizankowska-Mogilnicka E, Sanak M Hypersensitivity to aspirin and nonsteroidal antiinflammatory drugs in Adkinson NF, Busse WW, 19 Bochner BS, et al (eds) Middleton s Allergy, ed 7. St Louis, Mosby Elsevier, 2009, pp 1227-1243. 

Zembowicz A, Mastalerz L, Setkowicz M, Radzis-zewski W, Szczeklik A Histological spectrum of cutaneous reactions to aspirin in chronic idiopathic urticaria. J Cutan Pathol 2004 31 323-329. Mastalerz L, Setkowicz M, Sanak M, Szczeklik A Hypersensitivity to aspirin common eicosanoid alterations in urticaria and asthma. J Allergy Clin Immunol 2004 113 771-775. 

Antiplatelet therapy with aspirin should be considered for all patients without contraindications, particularly in patients with a history of myocardial infarction. Clopidogrel may be considered in patients with allergies or intolerance to aspirin. In some patients, combination antiplatelet therapy with aspirin and clopidogrel may be used. 

R. Weber, M. Hoffman, D. Raine, and H. Nelson, Incidence of bronchoconstriction due to aspirin, azo dyes, non-azo dyes and preservatives in a population of perennial asthmatics, J. Allergy Clin, immunol, 64, 32 (1979). 

Pierzchalska, M., Szabo, Z., Sanak, M., Soja, J., and Szczekhk, A. (2003) Deficient prostaglandin E-2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma. J. Allergy Clin. Immunol. Ill, 1041-1048. 

Hypersensitivity to dipyridamole, aspirin, or any of the other product components. Allergy Aspirin is contraindicated in patients with a known allergy to NSAIDs and in patients with asthma, rhinitis, and nasal polyps. Aspirin may cause severe urticaria, angioedema, or bronchospasms (asthma). 

Bismuth Subsalicylate (Pepto-Bismol) [Antidiarrheal/ Adsorbent] [OTC] Uses Indigestion, N, D combo for Rx of H. pylori Infxn Action Antisecretory anti-inflammatory E>o e Adults. 2 tabs or 30 mL PO PRN (max 8 doses/24 h) Feds. 3—6 y 1/3 tab or 5 mL PO PRN (max 8 doses/24 h) 5-9 y 2/3 tab or 10 mL PO PRN (max 8 doses/24 h) 9-72 y 1 tab or 15 mL PO PRN (max 8 doses/24 h) Caution [C, D (3rd tri), -] Avoid w/ renal failure Hx severe GI bleed Contra Influenza or chickenpox (T risk of Reye synd), ASA allergy (see Aspirin) Disp Chew tabs, caplets, Liq, susp SE May turn tongue stools black Interactions T Effects OF ASA, MTX, valproic acid effects OF tetracyclines i effects W/ corticosteroids, probenecid EMS Monitor for hypovolemia and electrolyte disturbances d/t D may darken tongue stool OD Similar to ASA OD V, tinnitus, metabolic acidosis activated charcoal may be effective... 

Contraindications Allergy to tartrazine dye, bleeding disorders, GI bleeding or ulceration, history of hypersensitivity to choline magnesium trisalicylate, aspirin, or NSAIDs. 

The following patient categories were excluded from the study patients with ostial and bifurcation lesions, left ventricular ejection fraction <30%, known hypersensitivity or contraindication to aspirin or stainless steel, or a sensitivity to contrast dye, allergy to heparin or ticlopidine,... 

Before starting any procedure needing local anesthesia, ask the patient if he or she has any allergies to anesthetics.Also inquire if the patient is on any anticoagulant medications (e g., aspirin, Coumadin, and heparin) that could create bleeding problems. 

Stevenson DD. Diagnosis, prevention, and treatment of adverse reactions to aspirin and nonsteroidal anti-inflammatory drugs. J Allergy CUn Immunol 1984 74 617-622. 

Stevenson DD, Simon RA, Zuraw BL. Sensitivity to aspirin and nonsteroidal anh-inflanunatory drags. In Adkinson NE Jr, Yunginger JW, BusseWW, etal, eds. Allergy Principles and Practice, Vol 2,6th ed. 2003 1695-1710. 

Gastric upset, heartburn, nausea, vomiting, anorexia, and gastrointestinal bleeding may occur witli salicylate usa Altliou i tliese dni are relatively safe when taken as recommended on tlie label or by tlie primary healtli care provider, tlieir use can occasionally result in more serious reactions. Some individuals are allergic to aspirin and tlie otlier salicylates. Allergy to tlie salicylates may be manifested by hives, rash, angioedema, bronchospasm witli astlima-like symptoms, and anaphylactoid reactions. 

FP has a history of cardiovascular disease, having survived a myocardial infarction that occurred in his mid-50s and, more recently, a stroke. Currently, he is on extended-release diltiazem (Cardiazem, 420 mg q.i.d.) and betaxolol HCI (Kerlone, 10 mg q.i.d.) for chronic stable angina coupled with hypertension. He also takes one baby aspirin each day. FP is troubled by rheumatoid arthritis, for which he takes diclofenac (Voltaren, 50 mg t.i.d.), and he has a documented allergy to sulfonamides. 

Weltman JK, Szaro RP, Settipane GA (1978) An analysis of the role of IgE in intolerance to aspirin and tartrazine. Allergy 34 273-281... 

Conroy MC, de Week AL (1981) The effect of aspirin and indomethacin on histamine release from leukocytes of petients with suspected intolerance to aspirin. Int Arch Allergy Appl Immunol [Suppl I) 66 152... 

Samter M, Beers RF (1967) Concerning the nature of intolerance to aspirin. J Allergy Clin Immunol 40 281... 

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