Allergic disease receptors associated with

Receptors Associated with Allergic Disease and Asthma... 

Devos, R., Plaetinck, G., Cornelis, S., Guisez, Y., Van der Heyden, J., and Tavernier, J. 1995. Interleukin-5 and its receptor a drug target for eosinophilia associated with chronic allergic disease. Journal of Leukocyte Biology 57, 813-818. 

Th2 cytokine IL-10 is an antiinflammatory cytokine that suppresses the secretion of proinflammatory cytokines (Dll), allergen-induced airway inflammation, and nonspecific airway responsiveness (T9). IL-13 shares a receptor component, signaling pathways, and many biological activities with IL-4. In fact, IL-13 is also an antiinflammatory cytokine and plays a unique role in the optimal induction and maintenance of IgE production and IgE-mediated allergic responses when IL-4 production is low or absent (DIO, W12). Moreover, IL-13 or IL-4 shows a synergistic effect with TNF-a or IL-5 on eosinophil activation (L20). Recently, IL-11 was found to be involved in the chronic remodeling seen in asthmatic airways and is associated with increasing severity of the disease (Ml6). 

Anakinra is an interleukin-1 receptor antagonist. It has been used to treat rheumatoid arthritis (1,2). It has been tried in graft-versus-host disease, but without success (3). According to published trial data, moderate injection site reactions were the primary adverse effect and required treatment withdrawal in under 5% of patients. An erythematous rash was seldom observed. Although a few patients have developed antibodies to anakinra, these have not so far been associated with lack of efficacy or allergic skin reactions. 

CCRl plays an important role in host defense and is involved in regulating the chemotaxis of immune cells, a feature it shares in common with all chemoldne receptors. Dysregulation of this response leads to autoimmunity and CCRl has been associated with the pathophysiology of a number of diseases including rheumatoid arthritis [7-9], multiple sclerosis [10-12], transplant rejection [13, 14] and allergic inflammation [15-17]. 

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