3-Alkylpyridinium from marine sponges

Table I. Cytotoxic activity of 3-alkylpyridine and 3-alkylpyridinium compounds from marine sponges on...

An excellent review paper on compounds from marine sponges with antifouling activity was written by Fusetani [56]. A recent review on the antifouling activity of 3-AP compounds, with special emphasis on the polymeric alkylpyridinium salts (poly-APS, 77) and their antifouling activity, was also recently published [57]. So far, poly-APS are the only 3-APs for which anti micro- and macro-fouling activity has been studied intensively. 

Sepcic, K. (2000) Bioactive alkylpyridinium compounds from marine sponges./. Toxicol. - Toxin Rev., 19, 139-160. 

Sepcic, K., Batista, U., Vacelet, J., Macek, P., and Turk, T. (1997) Biological activities of aqueous extracts from marine sponges and cytotoxicity effects of 3-alkylpyridinium polymers from Reniera sarai. Comp. Biochem. Physiol, 117C, 47-53. 

Bunc, M., Sepdc, K., Turk, T, and Suput, D. (2000) In vivo effects of head-to-tad 3-alkylpyridinium polymers isolated from the marine sponge Reniera sarai. Pjlugers Arch. Eur. J. Physiol, 440 (Suppk), R173-R174... 

Lavdle, R., Thomas, O.P., Berrue, F., Reyes, F., and Amade, P. (2008) Pachychalines A-C novel 3-alkylpyridinium salts from the marine sponge Pachychalina sp. Fur. J. Org. Chem., 121-125. 

Sepcic, K., Marcel, V., Klaebe, A., Turk, T, Suput, D., and Fournier, D. (1998) Inhibition of acetylcholinesterase by an alkylpyridinium polymer from the marine sponge, Reniera sarai. Biochim. Biophys. Acta, 1387, 217-225,... 

Laville, R., Amade, P., and Thomas, O.P. (2009a) 3-Alkylpyridinium salts from Haplosclerida marine sponges Isolation, structure elucidations, and biosynthetic considerations. Pure. Appl. Chem., 81, 1033-1040. 

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