3-Alkylpyridinium polymer from Reniera sarai

Sepcic, K., Batista, U., Vacelet, J., Macek, P., and Turk, T. (1997) Biological activities of aqueous extracts from marine sponges and cytotoxicity effects of 3-alkylpyridinium polymers from Reniera sarai. Comp. Biochem. Physiol, 117C, 47-53. 

Structures equivalent to those described above, and generally called polymeric alkylpyridinium salts (PAPS), have been isolated from Reniera sarai harvested in the Adriatic Sea at depths of 15—40 m. These polymers have anticholinesterase, cytotoxic and hemolytic activities, but the oligomers of molar mass less than 3000 Da show no activity (Sepcic et al., 1997,1998 Malovrh et al., 1999 Brmc et al., 2000, 2002). 

Sepcic, K., Marcel, V., Klaebe, A., Turk, T, Suput, D., and Fournier, D. (1998) Inhibition of acetylcholinesterase by an alkylpyridinium polymer from the marine sponge, Reniera sarai. Biochim. Biophys. Acta, 1387, 217-225,... 

Bunc, M., Sepdc, K., Turk, T, and Suput, D. (2000) In vivo effects of head-to-tad 3-alkylpyridinium polymers isolated from the marine sponge Reniera sarai. Pjlugers Arch. Eur. J. Physiol, 440 (Suppk), R173-R174... 

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