Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Alkylating agent, effect

Other catalysts which may be used in the Friedel - Crafts alkylation reaction include ferric chloride, antimony pentachloride, zirconium tetrachloride, boron trifluoride, zinc chloride and hydrogen fluoride but these are generally not so effective in academic laboratories. The alkylating agents include alkyl halides, alcohols and olefines. [Pg.509]

In eontrast, dialkylhalonium salts sueh as dimethylbromonium and dimethyliodonium fluoroantimonate, whieh we prepared from excess alkyl halides with antimony pentafluoride or fluoroantimonie acid and isolated as stable salts (the less-stable chloronium salts were obtained only in solution), are very effective alkylating agents for heteroatom eompounds (Nu = R2O, R2S, R3N, R3P, ete.) and for C-alkylation (arenes, alkenes). [Pg.104]

The alkyl halide must be one that reacts readily by an 8 2 mechanism Thus methyl and primary alkyl halides are the most effective alkylating agents Elimination competes with substitution when secondary alkyl halides are used and is the only reac tion observed with tertiary alkyl halides... [Pg.1008]

Equation 4 can be classified as S, , ie, substitution nucleophilic bimolecular (221). The rate of the reaction is influenced by several parameters basicity of the amine, steric effects, reactivity of the alkylating agent, and solvent polarity. The reaction is often carried out in a polar solvent, eg, isopropanol, which may increase the rate of reaction and make handling of the product easier. [Pg.380]

These compounds vary in their specific mechanism of action and often have different effects on the individual patients. Thus, they are generally used in combinations, eg, corticosteroids with an alkylating agent, or an antimetaboUte with a plant alkaloid in a rotating schedule. [Pg.406]

This method is based on the generation of the tetraalkylammonium salt of pyrrolidorle, which acts as a base. The method is compatible with a large variety of carboxylic acids and alkylating agents. The method is effective for the preparation of macrolides. [Pg.229]

Alkylating agent, a reactive chemical that forms a covalent bond with chemical moieties on the biological target (usually a protein). For instance, p-haloalkylamines generate an aziridinium ion in aqueous base that inserts into -SH, -CHOH, or other chemical structures in peptides. Once inserted, the effects of the alkylating agent are irreversible. [Pg.277]

Kimbrough RM, Gaines TB. 1968. Effect of organic phosphorus compounds and alkylating agents on the rat fetus. Arch Environ Health 16 805-808. [Pg.216]

One goal of our current investigation is to show that genetically important cellular constituents can initiate the release of an alkylating agent from the N-nitrosamide. This might explain how highly reactive diazohydroxide metabolites effect the alkylation of nucleic acids within the cell nucleus. Preliminary evidence ( ) summarised in Table II shows that the decomposition of... [Pg.111]

Mokrosz JL et al. (1995) Structure-activity relationship studies of CNS agents, XIX Quantitative analysis of the alkyl chain effects on the 5-HTlA and 5-HT2 receptor affinities of 4-alkyl-1-arylpiperazines and their analogs. Arch Pharm (Weinheim) 328(2) 143-148... [Pg.96]

The important features of this transition structure are (1) the chelation of the methoxy group with the lithium ion, which establishes a rigid structure (2) the interaction of the lithium ion with the bromide leaving group, and (3) the steric effect of the benzyl group, which makes the underside the preferred direction of approach for the alkylating agent. [Pg.52]

Apart from the alkyl halide-Lewis acid combination, two other sources of carbo-cations are often used in Friedel-Crafts reactions. Alcohols can serve as carbocation precursors in strong acids such as sulfuric or phosphoric acid. Alkylation can also be effected by alcohols in combination with BF3 or A1C13.37 Alkenes can serve as alkylating agents when a protic acid, especially H2S04, H3P04, and HF, or a Lewis acid, such as BF3 and A1C13, is used as a catalyst.38... [Pg.1015]


See other pages where Alkylating agent, effect is mentioned: [Pg.186]    [Pg.225]    [Pg.186]    [Pg.225]    [Pg.192]    [Pg.105]    [Pg.557]    [Pg.95]    [Pg.59]    [Pg.294]    [Pg.301]    [Pg.250]    [Pg.729]    [Pg.129]    [Pg.376]    [Pg.2]    [Pg.4]    [Pg.16]    [Pg.122]    [Pg.150]    [Pg.243]    [Pg.178]    [Pg.54]    [Pg.55]    [Pg.150]    [Pg.154]    [Pg.433]    [Pg.282]    [Pg.215]    [Pg.26]    [Pg.193]    [Pg.399]    [Pg.1]    [Pg.216]    [Pg.36]   


SEARCH



Agent Effects

Alkylating agents adverse effects

Alkylating agents alkylation

Alkylation agents

Receptor alkylating agents effect

© 2024 chempedia.info