Alkyl N-6 Substituted d-Lysergamides

ALD-52 (1-acetyl-d-lysergic acid diethylamide) is equally as active a LSD-25. ALA-10 (l-acetyl-d-lysergic acid ethylamine) is 1/10 as active as LSD. 1-Alkylation (e.g. R2 = methyl, ethyl) chain lengthening on the LSD-25 molecule decreases the activity of the parent substance (Jacob 1994). MLD-41 binds to serotonin receptors stronger than that of LSD-25. It has reported to be one third as active as LSD (Abramson 1958). N-6 Alkylation (R3) increases activity (Jacob 1994). 

Methysergide causes cardiac and pulmonary fibrosis, yet continued to be prescribed for migraines with FDA approval (Graham 1967). For preparation of 6-N substituted lysergamides (Niwaguchi 1976). Several open chain analogs of LSD and 6-substituted nicotinic acid derivatives have been created (Lehrfeld 1964) (Whittle 1963). For chloro, nitro and amino analogs of LSD and psilocin see (McKay 1963). 

Ergonovine (Ergometrine) (i-Lysergic acid N-(l-hydroxyethylamide) CH3 CHS CH20H OH 

Ergonovine and d-lysergic acid N-(l-hydroxyethylamide) occur in some Convolvulaceae and also some strains of Claviceps paspali. Both produce oxytocic action (contractions of the uterus), mydriasis (dilated pupils) and hjrperthermia. 

Dihydro-(+)-lysergic acid diethylamide has been reported to be 1.6 times weaker than LSD. Lumi LSD is inactive. (Abramson 1957). 

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