4-amino analog

Only equivocal chemical evidence appears to be available for the unsubstituted aminoimidazoles. The failure of 2-aminoimidazole to undergo diazotization was originally interpreted to indicate that it existed in the imino form more recently, the 4-amino analog has been reported to behave as a normal aromatic amine. The infrared spectra of substituted aminoimidazoles of type 192 193 were con-... 

Triamino-4-pyrimidone (211) and 2,4,5,6-tetraminopyrimidine (212) add DMAD and DEAD to give the isoxanthopterin-6-acetates and their 4-amino analogs (213)339 via Michael reactions starting with the most basic (5-)amino groups. 

Several 3(2iI)-pyridazinones are made from 3-chloropyridazines, such as 6-methyl-3(2.H)-pyridazinone, and the 6-chloro or 4-amino analog, or from the corresponding alkoxy compounds on acid or basic hydrolysis. 6-Chloro-3(2I/)-pyridazinone is best prepared... 

In an attempt to prepare potent analogs of neamine, Sitrin and colleagues [51] have synthesized a series of amino derivatives of neamine including 3 - and 4 -amino analogs, as well as their 3 - and 4 -epimers. However, all these amino neamine derivatives were found to be less active than the parent compound. 

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