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Alkaloids Isolation, Structure, and Application

Clycosidase-Inhibiting Alkaloids Isolation, Structure, and Application [Pg.111]

Glycosidase-inhibiting alkaloids from plants are classified into five structural classes polyhydroxylated pyrrolidines, piperidines, indolizidines, pyrrolizidines, and nortropanes. Furthermore, they also occur as the glycosides. This review describes recent studies on isolation, characterization, glycosidase inhibitory activity, and therapeutic application of the sugar-mimicking alkaloids from plants. [Pg.111]


I 5 ClYcosidase-Inhibiting Alkaloids Isolation, Structure, and Application OH nH... [Pg.132]

G. E. Martin, M. Solntseva and A. J. Williams, Applications of 15N NMR spectroscopy in alkaloid chemistry, in Modern Alkaloids Structure, Isolation, Synthesis and Biology, E. Fattorusso and O. Taglialatela-Scafati (eds.), Wiley, New York, 2008, pp. 409-476. [Pg.288]

This section consists primarily of total synthesis work. Most partial syntheses are to be found in Sections II and IV, and only those not previously discussed or those of particular interest are considered here. The last decade has produced relatively few new total syntheses of bisbenzylisoquinoline alkaloids, evidently because commercial applications that could not be filled with isolated or semisynthetic materials have not developed, and because instrumental methods have made structure proof by interrelation of new alkaloids with known materials increasingly easy. [Pg.115]

A recent communication by Kumar and co-workers reported the isolation of a new binary tetrahydrocarbazole-indole alkaloid, methyl 2-methyl-4-(iV-2")8-methyl-l",2",3",4"-tetrahydrocarbazol-l"a-ylindol-3 -yl butanoate (77), C27H30N2O2 from the root timber of Murraya gleniei (67). It exhibited spectral data characteristic of an indole with an ester function. The mass spectral fragments having m/z 231 and 184 indicated that it was a binary alkaloid consisting of C14H17N02 and Q3H14N units. The structure and stereochemistry of 77 were established by the application of 1H, 13C, DEPT,... [Pg.45]

Here, we will discuss the general strategies followed in the isolation, identification, and structure elucidation of alkaloids. The various methods will be briefly discussed separately, with special reference to the applications for alkaloid analysis. We will not try to give a complete review of all work done on the structure elucidation of alkaloids. For reviews on the different classes of alkaloids we refer to the series The Alkaloids, Volumes 1-5 edited by Manske and Holmes (1950-1955), Volumes 6-16 by Manske (1955-1977), Volumes 17-20 by Manske and Rodrigo (1979-1981) and later volumes by Brossi (1983-1992), and Alkaloids Chemical and Biological Perspectives edited by Pelletier (since 1983). Furthermore, numerous review articles on different groups of alkaloids have been published particularly on isoquinoline alkaloids a series of reviews has appeared in the Journal of... [Pg.1]

The earliest application of inverse-detected 2D NMR techniques to a terrestrial alkaloid of which we are aware was the assignment of the H and NMR spectra of the indolocarbazole alkaloid staurosporine (7) reported by Meksuriyeri and Cordell (1988). Later in 1988, Edwards et al. utilized HMQC in the elucidation of the structure of pumiliotoxin-A (10) and related indolizine alkaloids isolated from Panamanian poison frogs. These were the only applications of inverse-detected 2D NMR techniques in alkaloid to appear in 1988. We will thus begin with staurosporine (7) and proceed to related carbazole-based alkaloids before continuing to pumiliotoxin-A (10) and other terrestrial alkaloids. [Pg.56]

The physiological activity of extracts from yew species has been known for millennia. In 1856, Lucas (358) isolated a mixture of alkaloids, which he called taxine and, 100 years later, Graf (359) showed this to be a mixture of at least seven compounds. Over 250 taxane diterpenoids are now known. Paclitaxel (312) was isolated from Taxus brevifolia (the Pacific Yew) in 1967 [360, 361] and its structure determined by X-ray crystallography in 1971 (362). The discovery of its anticancer properties led to a huge amount of research into its extraction, synthesis, production, and application. Bristol-Myers Squibb trademarked the name Taxol for paclitaxel and they, other pharmaceutical companies and academic researchers have invested much into the study of pacUtaxel and the search for active analogues and prodrugs. Some of the more significant materials in this series are shown in Fig. 8.59. [Pg.333]

The application of chromatographic techniques to isolation, purification, structure elucidation, and identification procedures has created new possibilities and resulted in considerable progress in the important field of alkaloid research. [Pg.165]

Oxosilicine (163), a new alkaloid of a Malagasy plant, Hazunta silicicola Pichon, has an a-acylindole structure related to 20-epiervatamine. Although details of the isolation are still not available, the synthesis of (163) has already been announced (Scheme 19) this constitutes the first total synthesis of an alkaloid of the dihydrovobasine-ervatamine group. The major feature of the route adopted is that the acylindole linkage is formed at the outset, and the bond to C-7 (indole jS -position) formed much later. This route may well be applicable to the synthesis of other 2-acylindole alkaloids. [Pg.218]


See other pages where Alkaloids Isolation, Structure, and Application is mentioned: [Pg.61]    [Pg.144]    [Pg.269]    [Pg.287]    [Pg.582]    [Pg.287]    [Pg.56]    [Pg.47]    [Pg.136]    [Pg.1]    [Pg.226]    [Pg.248]    [Pg.245]    [Pg.287]    [Pg.177]    [Pg.158]    [Pg.88]    [Pg.220]    [Pg.1039]    [Pg.10]    [Pg.136]    [Pg.128]    [Pg.1349]    [Pg.80]    [Pg.383]    [Pg.271]    [Pg.372]    [Pg.75]    [Pg.42]    [Pg.18]    [Pg.141]    [Pg.369]    [Pg.583]    [Pg.1888]    [Pg.306]   


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