Alginate spheres

In this case, unilamellar vesicles with a large capture volume were prepared by the reverse phase evaporation technique and alginate was used to microencapsulate the liposome s. The alginate spheres were double coated, first with poly-L-lysine and then with polyvinyl amine (Wheatley and Langer in press). 

Applying this technique, calcium cross-linked alginate spheres can be used as targets for the radiation cross-linking of PVME to obtain PVME microgel particles [46], The dimension of the PVME particles is defined by the droplet size of the alginate beads. For the synthesis, PVME is incorporated into alginate beads... 

It has been shown that a modified drug release can be obtained from calcium alginate microcapsules, pellets, and microspheres. When biodegradable bone implants composed of calcium alginate spheres and containing gentamicin were introduced into the femur of rats, effective drug levels in bone and soft tissue were obtained for 30 days and 7 days, respectively. ... 

With ferrite microparticles dispersed together with insulin in alginate spheres, the rate of insulin release in vitro was reported to be 50 times higher in the presence than in the absence of a magnetic field (Saslawski et al,... 

Next drop-wise introduce the clay/alginate suspension into a CaCl, - solntion [2% m/v under constant stirring. At the correct stirringspeed nearly perfect spheres are formed. 

An enzyme which hydrolyzes the cellobiose to glucose, /3-glucosidase is immobilized in a sodium alginate gel sphere (2.5 mm in diameter). Assume that the zero-order reaction occurs at every point within the sphere with k0 = 0.0795 mol/sm3, and cellobiose moves through the sphere by molecular diffusion with Ds = 0.6 x 10 5 cm2 /s (cellobiose in gel). Calculate the effectiveness factor of the immobilized enzyme when the cellobiose concentration in bulk solution is 10 mol/m3. 

Bums, M., Kvesitadze, G. I., and Graves, D., "Dried alginate/magnetite spheres a new support for chromatographic separations and enzyme immobilization" Biotech. Bioeng. 1985. 27 137-145. 

Y. Senuma, C. Lowe, Y. Zweifel, J. G. Hilbom, and I. Marison. Alginate hydrogel micro-spheres and microcapsules prepared by spinning disk atomization. Biotechnology and Bioengineering, 67(5) 616-622, 2000. 

The vibration system is theoretically based on liquids with Newtonian flnid dynamics however, it was reported by Serp et al. that it can be applied to non-Newtonian liquids such as alginate, to make uniform drops and therefore microspheres by ionotropic gelation." The different equations can thereby be used as an approximation of the frequency and flow rates needed to break up the polymer into particles, however, it was suggested by Serp et al. and by Whelehan and Marison to determine the required values for a given nozzle diameter with an empirical approach for each system in which the calculated value is used as a starting (reference) point." It must also be noted that the size of the droplet does not necessarily equal the size of the produced bead/sphere. ... 

Burns, M. A. and Kvesitadze, G. I. Dried calcium alginate/magnetite spheres A new support for chromatographic separations and enzyme immohilization. Biotechnol. Bioeng. 27 (1985) 137. 

Ciofani et al. (2008) studied the preparation and properties of a drug delivery system based on calcium alginate microgels. For the experiments were used gels in three different forms (spheres, films, and libers) obtained from 100 pL of a 1 %w/ w sodium alginate solution containing the tested protein. Spheres were prepared by... 

Amphiphilic peptides lonically crosslinked micro- and nano-spheres Biotinylated microspheres Photopolymerizable hydrogels Thermally activated crosslinked gels Two-component polyurethanes Alginates... 

F. (2012) Alginate and alginate/gelatin micro-spheres for human adipose-derived stem cell encapsulation and differentiation. Biofabrication, 4, 025007. 

Encapsulation of bioactive or cellular material for biotechnical or biomedical applications in spheres formed by alginate gelation [28] Continuous processing [3, 21, 26-28]... 

In a trial, alginate was crosslinked with hyaluronate, which are both pH-responsive biomaterials, as encapsulation agents in the form of microspheres. The spherical micro-spheres presented promising loading and release behaviors in the simulated gastrointestinal tract media [69]. 

This reaction is recreated in the application of chemistry to cuisine, when adventurous, science-minded chefs cook with spherification. They turn practically any liquid, from green tea to apple juice, into small spheres that burst on the tongue like caviar. The secret is to mix calcium with an oxidized sugar strand like alginate. The... 

Figure 1 shows the time course of the shape of magnetic gel beads showing rotational motion. As seen in Figure 1(a), the bead was turbid and it had a shape of sphere with rough surface. Sodium alginate was soluble in water however keto-profen was insoluble in water, but soluble in methanol. Immediately after mixing... 

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