Alfuzosine

Alfuzosin (91) is a prazosin-like hypotensive adrenergic a-1 receptor blocker with the special structural feature that two carbons have been excised conceptually from the piperazine ring normally present in this series. Following the usual sequence for this series, reaction of 4-amino-2-chloro-7-dimethoxyquinazoline (89) with the tetrahydro-2-furyl amide of 3-methylaminopropyla-mine (90) gives alfuzosin (91) [25], Alfuzosin is claimed to cause less orthostatic hypotention (dizziness or fainting upon sudden rising) than prazosin. [Pg.149]

C7H, N303 55559-70-1) see Cidofovir 6-amino-2,4-dihydroxypyrimidine (C4H5N3O2 143505-00-4) see Sulfadimethoxine 2-amino-2, 5 -dimethoxy acetophenone (Ck,H 3N03) see Midodrine 2-amino-4,5-dimethoxybenzamide (C,j1I 2N203 5004-88-6) see Alfuzosin... [Pg.2292]

C20H30O3 JIIJ4-09-7) see Oxymesterone Af -methyl-A -tetrahydrofuroyltrimethylenediainine (Ci)HisN202 81403-67-0) see Alfuzosin... [Pg.2423]

C 7H,203 5675-70-7) see Bisantrene (R)-(-i)-tetrahydrofuran-2-carboxylic acid (CjHgOj 87392-05-0) see Faropenem sodium ( )-tetrahydrofuran-2-carboxylic acid (CjHgOg 16874-33-2) see Alfuzosin Faropenem sodium tetrahydro-2-furancarboxylic acid anhydride with ethyl hydrogen carbonate (CgHijO, 167391-50-6) see Alfuzosin... [Pg.2443]

CH4N2O 57-13-6) see Alfuzosin Allantoin Amobarbital Barbital Bromisoval Butalbital Carbasalate calcium Carbromal Cyclopentobarbital Dimethadione Dipyridamole Enoximone Ethotoin Heptabarb Metaxalone Methyclothiazide Orotic acid Paramethadione Pentobarbital Phenacemide Phenetuiide Phenobarbital Phenytoin Proquazone Secbutabarbital Secobarbital Sulfadimethoxine Thalidomide Trimethadione... [Pg.2453]

Among the a-adrenergic antagonists, alfuzosin is considered functionally uroselective because in usual therapeutic doses, it produces relaxation of the bladder neck and prostatic smooth... [Pg.791]

Requirement for up-titration of dose Yes (for terazosin and doxazosin immediate-release) no (for alfuzosin possibly for doxazosin extended-release and tamsulosin) No... [Pg.797]

Need for up-titration of daily dose. Up-titration is required for terazosin and immediate-release doxazosin. It is minimally required for extended-release doxazosin and tamsulosin. It is not required for extended-release alfuzosin. [Pg.798]

Dosage formulation. Immediate-release formulations of terazosin and doxazosin are quickly absorbed and produce high peak plasma levels. Modified- or extended-release formulations of doxazosin, alfuzosin, and tamsulosin produce lower peak levels, but more sustained therapeutic plasma levels, than immediate-release formulations and have less potential for producing hypotensive episodes, thereby allowing initiation of treatment with a therapeutic dose and once daily dosing.25-27... [Pg.798]

Alfuzosin has been linked to two cases of hepatitis.2930 The cause-effect relationship remains to be elucidated. [Pg.799]

Prazosin (Minipress) Alfuzosin (Uroxatral) Terazosin (Hytrin) Doxazosin (Cardura) Tamsulosin (Flomax) Finasteride (Proscar) Dutasteride (Avodart) Bicalutamide (Casodex) Flutamide (Eulexin) Leuprolide (Lupron) Nafarelin (Synarel) Megestrol acetate... [Pg.946]

Figure 12.4, where an initial molecule, Alfuzosin, with three cleavage points and three resulting fragments are shown. [Pg.292]

Q14 Alfuzosin is used in benign prostatic hyperplasia because it ... [Pg.6]

Alfuzosin is a selective alpha-blocker, which relaxes smooth muscle, thereby increasing urinary flow rate. Because of its alpha-blockade effect, alfuzosin tends to lower the blood pressure and the first dose of the drug may lead to a hypotensive effect. [Pg.30]

Q49 When dispensing alfuzosin hydrochloride, the patient should be advised to ... [Pg.55]

Alfuzosin is a selective alpha -blocker, which relaxes the smooth muscle in benign prostatic hyperplasia and hence increases the urinary outflow. [Pg.76]

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