Cimetidine Alfuzosin

Clinically important, potentially hazardous interactions with alfuzosin, alprazolam, amphotericin B, anisindione, antacids, aprepitant, astemizole, atorvastatin, bosentan, ciclesonide, cimetidine, clorazepate, conivaptan, cyproterone, dasatinib, dexamethasone, dicumarol, didanosine, eplerenone, erythromycin, ethotoin, fentanyl, fesoterodine, fosamprenavir, fosphenytoin, grapefruit juice, HMG-CoA reductase inhibitors, imatinib, ixabepilone, lapatinib, lopinavir, lovastatin, mephenytoin, methylprednisolone, micafungin, midazolam, nilotinib, pimozide, prednisolone, prednisone, quinidine, rifampin, rimonabant, rivaroxaban, sildenafil, silodosin, simvastatin, sirolimus, solifenacin, temsirolimus, terfenadine, tolvaptan, triazolam, vardenafil, vinblastine, vincristine, warfarin... 

Desager JP, Harvengt C, Bianchetti G, Rosenzweig P. The effect of cimetidine on the pharmacokinetics of single oral doses of alfuzosin. IntJ Clin Pharmacol Ther Toxicol (1993) 31,568-71. 

No important interaction occurs between cimetidine and either alfuzosin or doxazosin. Tamsulosin does not appear to have a clinically significant interaction with cimetidine, but caution is recommended with high tamsulosin doses. 

In 10 healthy subjects cimetidine 1 g daily in divided doses for 20 days was found to have minimal effects on the pharmacokinetics of a single 5-mg dose of alfuzosin. The maximum serum levels and AUC of alfuzosin were increased by up to 24%, (not statistically significant) and the half-life was shortened by 14%. Cimetidine did not appear to increase the incidence of postural hypotension seen with alfuzosin. These changes are... 

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