Alfuzosin Atenolol

The risk of first-dose hypotension with prazosin is higher if the patient is already taking a beta blocker. This is also likely to be true of other alpha blockers, particularly alfuzosin, bunazosin and terazosin. In a small study tamsulosin did not have any clinically relevant effects on blood pressure that was already well controlled by atenolol. Alpha blockers and beta blockers may be combined for additional lowering of blood pressure in patients with hypertension. 

No pharmacokinetic interaction occurred between alfuzosin 2.5 mg and atenolol 100 mg in a single-dose study in 8 healthy subjects. The manufacturer notes that postural hypotension may occur in patients receiving antihypertensives when they start alfuzosin, and note a study in which the combination of single doses of alfuzosin 2.5 mg and atenolol 100 mg caused significant reductions in mean heart rate and blood pressure. The AUCs of both drugs were raised up to about 20%. ... 

Bianchetti G, PadovaniP, Coupez JM, GuinebaultP, HermannsP, Coupez-LopinotR, Guillet P, Thenot JP, Morselli PL. Pharmacokinetic interactions between hydrochlorothiazide, atenolol, and alfuzosin a new antihypertensive drug. Acta Pharmacol Toxicol (Copenh) (1986) 59 (Suppl 5), 197,... 

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