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Alcoholic solvents, inclusion

The inclusion of alcoholic solvents, for example, isopropanol, has been advocated for insoluble drugs such a norethindrone and was used to provide a rank order of dissolution. " The dissolution rates increased in hydroalcoholic medium. Each component of a nor-ethindrone-mestranol combination tablet gave its own... [Pg.921]

For example, the same dimer complex which contains two molar equivalents of ethanol, underwent photoreaction to give a higher molecular weight polymer (M = 12 000). The formation of such inclusion complexes with the solvent is rather generally observed with similar types of dimers formed with alcohols and some other solvents and, consequently, this enhances photopolymerizability. Such complex formation with a solvent may be one of the promising techniques that can be used for diolehn compounds in order to obtain polymers with high molecular weights. [Pg.164]

Anthraquinone glycosides and aglycones can be readily separated on silica layers rising moderately polar developing solvents [41 3]. The best such solvents eonsist of ethyl acetate modified to increase polarity by the addition of alcohols or water for the glycosides or changed to decrease polarity by inclusion of hydrocarbon components. [Pg.344]

The question arises, whether and to what extent the dicarboxylic acid 1 is capable of binding other solvents besides ethanol (starting observation, cf. Sect. 1) in the crystal lattice. For this purpose, to begin with, crystallization experiments using further alcohols (straight-chain, branched, univalent and polyvalent) were carried out. It was found that 1 is apt to form crystal inclusions on a large scale, i.e. with alcohols of various constitutions. A list of different examples is given in Table 1 (Entries 1-16). [Pg.64]

Another remarkable fact is that methanol acts as a suitable guest for 37 whereas long-chain alcohols are ineffective. The opposite is true for 26. Since ethanol which is the next higher homologue of methanol does not lead to a corresponding crystal inclusion with 37 (the same applies for 31), crystallization of 37 (or 31) from respective solvent mixtures provides an easy way to separate methanol from ethanol,... [Pg.77]

A method for determining optical purities of less than one percent for secondary alcohols has been published, and Mislow has observed a partial resolution which may serve to distinguish between a meso and a racemic host product when a derived inclusion compound is recrystallized from an enantiomerically enriched guest solvent. ... [Pg.8]

Lipids in starchy foods may occur in the free as well as bound forms. The latter being either in the form of amylose inclusion complexes or linked via ionic or hydrogen bonding to the hydroxyl groups of the starch components. Free lipids are easily extractable at ambient temperatures, while use of nonalcoholic solvents for a prolonged period or disruption of the granular structure by acid hydrolysis (see Basic Protocol 4) may be required for the efficient extraction of bound lipids. While acid hydrolysis allows the release and quantitation of lipids, the procedure leads to destruction of the starch components therefore, the alcohol extraction system involving propanol and water would be most desirable in these cases. This system removes both nonpolar and polar lipids from samples. [Pg.431]

The fluorescent intensities of the E vitamers are highly dependent on the solvent. Polar solvents such as diethyl ether and alcohols provide greater intensities compared with hexane. The fluorescence is negligible when the compounds are dissolved in chlorinated hydrocarbons (137). The inclusion of an ether or an alcohol in the hexane mobile phase increases the sensitivity of vitamin E detection measurably in normal-phase HPLC. [Pg.355]

It was quite unexpectedly found that the amorphous samples of zirconium and hafnium alkoxides M(OR)4 contain several types of oxocomplexes, particularly, M3O(OR)i0 and M40(0R)14 [1612], The trinuclear Zr3([l3-0)()i3-OBu XOBu ), was isolated in a crystalline form and turned out to be a structural analog of the known isopropoxide clusters of Th, Mo, and U(IV) -MjOCOPr ),) [1520] (see also Sections 4.3 and 12.12). The inclusion of the solvent molecules inside the cavities of the structures and formation of alcohol solvates in many cases leads to microanalysis data that does not deviate much from those calculated for M(OR)n. [Pg.70]

If an achiral ferrocene derivative is converted to a chiral one by chiral reagents or catalysts, this may be called an asymmetric synthesis. All asymmetric syntheses of ferrocene derivatives known so far are reductions of ferrocenyl ketones or aldehydes to chiral secondary alcohols. Early attempts to reduce benzoylferrocene by the Clemmensen procedure in (5)-l-methoxy-2-methylbutane as chiral solvent led to complex mixtures of products with low enantiomeric excess [65]. With (25, 3R)-4-dimethylamino-l,2-diphenyl-3-methyl-2-butanol as chiral modifier for the LiAlH4 reducing agent, the desired alcohol was formed with 53% ee (Fig. 4-9 a) [66]. An even better chiral ligand for LiAlH4 is natural quinine, which allows enantioselective reduction of several ferrocenyl ketones with up to 80% ee [67]. Inclusion complexes of ferrocenyl ketones with cyclodextrins can be reduced by NaBH4 with up to 84% enantioselectivity (Fig. 4-9 b) [68 — 70]. [Pg.181]

Detailed analyses of intramolecular structures are possible. Comparison of NMR and fluorescence data shows meso- and racemic diastereoisomers are found from 2,4-di(2-pyrenyl)pentane 24 jhe polarization of monomer and excimer of 4,9, disubstituted pyrenes have been measured in nematic liquid crystals 25 Quenching of pyrene fluorescence by alcohols in cyclodextrin inclusion complexes has also been studied in detail 26 Solvent effects on the photophysical properties of pyrene-3-carboxylic acid has been used to measure the pJJ, in different solvents 27 Geminate recombination in excited state proton transfer reactions has been studied with... [Pg.12]

KoUer et al. (45) investigated the effect of the structure of the alcohol on the retentions (k ) and enantioselectivities (a) for three enantiomeric solutes on the CTA-I CSP In the series methanol, ethanohwater (96 4), 2-propanol, the k of each enantiomer increased through the series, whereas the effect on the observed a s varied. The authors concluded that the polarity of the eluents may not be the key to their elutropic strength. Instead, the elutropic strength of the solvent may be a function of the steric bulk of the alcohol. By binding to sites near or at the site of inclusion, the alcohol can affect the steric environment of the channels and cavities, thereby changing the fit on the solutes into these cavities, This, in turn, would alter both k and a. [Pg.149]

The study of CIPs and SSIPs and their reactivity with alcoholic nucleophiles. This includes the specific inclusion of solvent as in Section III.2, point 3. It also entails solving many body interactions such as in point (1). [Pg.146]


See other pages where Alcoholic solvents, inclusion is mentioned: [Pg.437]    [Pg.922]    [Pg.403]    [Pg.32]    [Pg.2574]    [Pg.75]    [Pg.440]    [Pg.127]    [Pg.163]    [Pg.267]    [Pg.483]    [Pg.67]    [Pg.71]    [Pg.75]    [Pg.78]    [Pg.368]    [Pg.677]    [Pg.225]    [Pg.124]    [Pg.165]    [Pg.51]    [Pg.44]    [Pg.44]    [Pg.553]    [Pg.75]    [Pg.186]    [Pg.348]    [Pg.16]    [Pg.78]    [Pg.143]    [Pg.351]    [Pg.1039]    [Pg.97]    [Pg.3225]    [Pg.111]    [Pg.173]    [Pg.760]   
See also in sourсe #XX -- [ Pg.921 ]




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