Airway remodeling, in asthma

Redington AE (2001) Airway remodeling in asthma. CME Bull Respir Med 3 37-40. 

Elias JA. 2000. Airway remodeling in asthma. Am J Respir Crit Care Med. 161 S168-S171. 

Strong associations have been shown between IL-13 polymorphisms and atopy -related phenotypes in two studies of children [135(111), 138(111)], however, neither of these studies examined associations with asthma. In contrast, in adults, polymorphisms in IL-13 are associated with asthma not IgE levels [136(111), 139(111)]. Thus, it is possible that polymorphisms in IL-13 may confer susceptibility to airway remodelling in asthma, as well as to allergic inflammation in early life. 

Elias JA, Zhu Z, Chupp G, Homer RJ. Airway remodeling in asthma. J Clin Invest 1999 104 1001-1006. 

Ammit, A.J., Hastie, A.T., Edsall, L.C., Hoffman, R.K., Amrani, Y., Krymskaya, V.P., Kane, S.A., Peters, S.P., Penn, R.B., Spiegel, S., and Panettieri, RA Jr., Sphingosine 1-phosphate modulates human airvray smooth muscle cell functions that promote inflammation and airway remodeling in asthma, FASEB J, 15 (2001) 1212-1214. 

C. FoUi, D. Descalzi, F. Scordamaglia, A.M. Ricdo, C. Gamalero, G.W. Canonica, New insights into airway remodelling in asthma and its possible modulation, Curr. Opin. Allergy CUn. Immunol. 8 (5) (October 2(X)8) 367—375. 

Another potential advantage of extra-fine corticosteroid aerosols is their apparently greater accessibility to peripheral airways (< mm in diameter) which appear to be poorly penetrated by conventional CFC-based aerosols. Recent data indicate that airway inflammation is present in both large and small airways, as well as alveolar tissue, and that airway wall remodeling occurs in small airways. The clinical significance of small airways involvement in asthma, its contribution to fatal asthma or to the accelerated rate of decline in lung function with age that occurs in asthma, and the consequences of treating the small airways component... 

Fahy JV, Corry DB, and Boushey HA. Airway inflammation and remodeling in asthma. Curr Opin Pulmon Med 2000 6 15-20. 

Bento AM, MB Hershenson. 1998. Airway remodeling potential contributions of subepithehal fibrosis and airway smooth muscle hypertrophy/hyperplasia to airway narrowing in asthma. Allergy Asthma Proc 19 353. 

Redington A, Howarth P. Airway wall remodelling in asthma. Thorax 1997 52 310-312. 

Holgate S, Lackie P, Davies D, Roche W, Walls A. The bronchial epithelium as a key regulator of airway infiammation and remodelling in asthma. Clin Exp Allergy 1999 29 90-95. 

Airway inflammation, and probably its effects on airway structure (airway remodeling), are considered to be responsible not only for the acute but also the longterm changes in airway function in asthma such as persistent airway responsiveness and variable airflow obstruction (56-59). 

Asthma is a chronic inflammatory condition characterized by bronchial hyper-responsiveness and reversible airway obstruction. Cytokine release from a variety of cell types such as eosinophils, lymphocytes and other inflammatory cells produces epithelial sloughing, plasma protein extravasation from the tracheobronchial microcirculation and airway remodeling. Bronchial mucosal inflammation is present in all patients. The primary goal of asthma management is to maintain control of the disease process by reducing symptoms and improving lung function. 

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