Agre, Peter

Peter Agre, M.D. 2003 Nobel Prize winner in Chemistrg... 

Peter Agre United States discovery of water channels ... 

A family of integral proteins discovered by Peter Agre, the aquaporins (AQPs), provide channels for rapid movement of water molecules across all plasma membranes (Table 11-6 lists a few examples). Ten aquaporins are known in humans, each with its specialized role. Erythrocytes, which swell or shrink rapidly in response to abrupt changes in extracellular os-molarity as blood travels through the renal medulla, have a high density of aqua-porin in their plasma membranes (2 X 105 copies of AQP-1 per cell). In the nephron (the functional unit of the kidney), the plasma membranes of proximal renal tubule cells have five different aquaporin types. 

Award of the Nobel prize for Chemistry to Peter Agre and Roderick MacKinnon for their discovery of... 

Two chemists, Peter Agre and Roderick MacKinnon3 received the Nobel prize in 2003 for their work on ion channels in cells and living tissues. These channels can selectively filter K+ ions and Na+ ions from solution. If the transport of these ions cascades, they can cause muscles to contract, cause eyes to water and malfunction of the brain cells and stop the cells ability to intercommunicate. This could result in cardiovascular problems, liver malfunction, dehydration and other disorders. 

The Nobel Prize in chemistry for 2003 went to Peter Agre for research on aquaporins and to Roderick MacKinnon for research on potassium channels. 

Peter Agre, Roderick Macklnnon Water channels and structural and mechanistic studies of ion channels. 

The channels (now called aquaporins) were discovered serendipitously. Peter Agre noticed a protein present at high levels in red-blood-cell membranes that had been missed because the protein does not stain well with Coomassie brilliant blue. This protein was found to be present in large... 

A family of integral proteins discovered by Peter Agre, the aquaporins (AQPs), provide channels for rapid... 

Peter Agre, Roderick MacKinnon 1949 WiUiam F. Giauque... 

Murthy L, Petering HG. 1976. Effect of dietary zinc and copper interrelationships on blood parameters of the rat. Agr Food Chem 24 808-811. 

Basic information on the mechanical analysis of biomembrane deformation can be found in Evans and Skalak [1979], which also appeared as a book under the same title (CRC Press, Boca Raton, FL, 1980). A more recent work that focuses more closely on the structural basis of the membrane properties is Berk et al, chapter 15, pp. 423-454, in the book Red Blood Cell Membranes Structure, Function, Clinical Implications edited by Peter Agre and John Parker, Marcel Dekker, New York, 1989. More detail about the membrane structure can be found in other chapters of that book. 

US biochemist Peter Agre (1949- ) identifies a water-channel protein (aquaporin) in the plasma membrane of cells. 

Edited by Stefan Hohmann, Spren Nielsen and Peter Agre... 

Peter Agre, Roderick MacKinnon 1946 James B. Sumner, John H. Northrop, Wendell M. Stanley... 

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