Aggregation, protein digestibility

Inhibits platelet aggregation by increasing levels of cAMP Binds protein C, which is then cleaved by thrombin to yield activated protein C this in combination with protein S degrades factors Va and Villa, limiting their actions Activates plasminogen to plas-min, which digests fibrin the action of t-PA is opposed by plasminogen activator inhibitor- (PAI-1)... 

In the case of cold-induced aggregation and gelation, two different types of gel microstructure, namely filamentous and particulate (Figure 2.1), have been obtained by adding different concentrations of a ferrous salt to solutions of pre-denatured p-lactoglobulin (the major whey protein). This substantial difference in microstructure turns out to have a major impact on the iron delivery, due to the different sensitivities of the structures to the relevant environmental conditions, such as pH and the presence of digestive enzymes. In particular, the filamentous gel micro-... 

Heinegard, D., Hascall, V. G Aggregation of cartilage proteoglycans. 3. Characteristics of the proteins isolated from trypsin digests of aggregates. J. Biol. Chem. 249, 4250 (1974)... 

Studies performed over the years have contributed to better understanding of the interactions between proteins and tannins, which are important not only due to their astringency but also because of their impact on food nutritional characteristics, on human health, and on plant metabolism. It is clear that protein-tannin interactions are influenced by several factors, among which polysaccharides could be important because they are also present in tannin-rich vegetables. Much remains to be studied in this field, particularly the specific phenomenon that occurs between proteins, tannins, and polysaccharides that leads to a decrease in aggregation, and further studies are needed involving other salivary proteins and digestive enzymes. 

Gastric or intestinal digestion Cellular protein turnover Post-mortem tenderization of meat Aggregation of polypeptide chains Blood clotting Activation of precursors Complement action Cleavage of presecretory proteins... 

Figure 9-1 The highlights of the chick embryonic neural retina micromass cultures are depicted. The tissue is harvested and digested to a single-cell suspension. These are placed into culture, and after 24 h three parameters are measured (a) the number of aggregates that are produced, (b) the size of the aggregates, and (c) their protein content. After five days cortisol is added to precociously induce glutamine synthetase activity. This is measured two days later, after a total of seven days of culture. Each parameter is uniquely sensitive to different agents, but a decrease in any one parameter is considered to be toxicologically relevant.

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