Age-Related Changes in Pharmacokinetics

Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics basic principles and practical applications. Br J Clin Pharmacol. 2004 57 6-14. [Pg.38]

Age-Related Changes in Pharmacokinetics Predictability and Assessment Methods Emilio Perucca... [Pg.461]

Age-related changes in pharmacokinetics t free drug concentration... [Pg.19]

Developmental changes produce differences in the absorption, metabolism and excretion of drugs. These age-related changes in pharmacokinetics have been used as determinants in the development of age-specific dose recommendations. [Pg.10]

Natiuretic response to diuretics including fruse-mide and bumetanide is reduced as a result of decreased renal tubular secretion of diuretic Thus, age-related changes in renal tubular function may influence not only pharmacokinetics but also drug action on the kidney (pharmacodynamics). [Pg.208]

Age-related alterations in pharmacokinetics (absorption, distribution, metabolism, and excretion) have received considerable attention. Thus, physiological changes in elderly patients, when taken together, may contribute to impairments in drug clearance in this segment of the population (Table 6.5). [Pg.59]

Grandison, M.K. and Boudinot, ED. (2000) Age-related changes in protein binding of drugs implications for therapy. Clin Pharmacokinet 38 271-290. [Pg.53]

Although there is no age-related change in fluvoxamine plasma levels, fluvoxamine has nonlinear and sex-dependent pharmacokinetics ( 304). A doubling of the dose from 50 to 100 mg twice a day causes, on average, a 340% increase in fluvoxamine plasma levels, which is more pronounced in men (460%) than in women (240%). [Pg.137]

Birnbaum LS Pharmacokinetic basis of age-related changes in sensitivity to toxicants. Annu Rev Pharmacol Toxicol 1991 31 101. [PMID 2064370]... [Pg.1282]

Woodhouse, K.W. and Wynne, H.A., Age-related changes in liver size and hepatic blood flow. The influence on drug metabolism in the elderly, Clin. Pharmacokinet., 15, 287, 1988. [Pg.34]

McMahon TF, Medinsky MA, Bimbaum LS. 1994. Age-related changes in benzene disposition in male C57BL/6N mice described by a physiologically based pharmacokinetic model. Toxicol Lett 74(3) 241-253. [Pg.399]

With respect to the pharmacokinetics and pharmacodynamics of specific cancer chemotherapy drugs in older patients, the goal is to achieve a desired tissue exposure to the drug(s) in the context of the age-related changes in drug disposition described in other sections of this chapter. Specific for anticancer... [Pg.383]

The two factors responsible for increasing risks of ADRs in children are pharmacokinetic changes and dose delivery issues. Age-related differences in pharmacokinetics in children are documented. However, the data on both efficacy and safety are often limited or not studied at all in this population. Thus, it is unclear whether an increased risk for ADRs exists in this group. However, there is a potential risk for increased ADRs if appropriate considerations are not taken into account in view of pharmacokinetic changes. ... [Pg.48]

Norman W M, Court M H, Greenblatt D J 1997 Age-related changes In the pharmacokinetic disposition of diazepam in foals. American Journal of Veterinary Research 58 878-880... [Pg.153]

American Journal of Veterinary Research 61 1579-1586 Nolan A, Reid J, Welsh E et al 1996 Simultaneous infusions of propofol and ketamine in ponies premedicated with detomidine a pharmacokinetic study. Research in Veterinary Science 60 262-266 Norman W M, Court M H, Greenblatt D J 1997 Age-related changes in the pharmacokinetic disposition of diazepam in foals. American Journal of Veterinary Research 58 878-880... [Pg.306]

Tagawa, Y., Kokue, E., Shimoda, M. Son, D. (1994) ai-Acid glycoprotein-binding as a factor in age-related changes in the pharmacokinetics of trimethoprim in piglets. [Pg.266]

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