Cancer chemotherapy specific drugs

Poste, G., and Kirsh, R. (1983). Site-specific (targeted) drug delivery in cancer chemotherapy. Biotechnology, 1, 869-878. 

The most important application recently developed for synthetic liposomes is as potential drug carriers for controlled release, especially for cancer chemotherapy (7). In general, the success of liposomes as vehicles for the transport of specific drugs will largely depend on their stability under physiological conditions. Unlike the naturally occurring membranes, the synthetic vesicles have very limited stability, and this is a... 

Wacher, V. J., Wu, C. Y., Benet, L. Z., Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein implications for drug delivery and activity in cancer chemotherapy, Mol. Carcinogen. 1995, 13, 129-134. 

Wacher VJ, Wu CY and Benet LZ (1995) Overlapping Substrate Specificities and Tissue Distribution of Cytochrome-P450 3a and P-Glycoprotein—Implications for Drug-Delivery and Activity in Cancer-Chemotherapy. Mol Carcinog 13 pp 129-134. 

There is another important aspect of DNA damages. A unique feature of many cancerous tumors is the existence of hypoxic regions, that is, regions of oxygen-poor cells (J.M. Brown 1999). Such cells are often resistant to more conventional forms of antitumor treatment, such as radiotherapy and chemotherapy (Denny Wilson 2000). There has been considerable effort to identify potential antitumor drugs that specifically target such cells. One such class of potential hypoxia-specific drugs is the benzotriazine A, A -dioxides, of... 

When cancer is diagnosed, three primary treatment modalities are available surgery, radiation treatment, and cancer chemotherapy. The purpose of this chapter is to describe the basic rationale of cancer chemotherapy and to provide an overview of the drugs that are currently available to treat specific forms of cancer. Rehabilitation specialists will routinely work with patients undergoing cancer chemotherapy. For reasons that will become apparent in this chapter, these drugs tend to produce toxic effects that directly influence physical therapy and occupational therapy procedures. Therefore, this chapter should provide therapists with a better understanding of the pharmacodynamic principles and beneficial effects, as well as the reasons for the potential adverse effects of these important drugs. 

In the search for possible targets the inhibition activity of a range of RAPTA compounds was studied for two specific enzymes - namely thioredoxin reductases (TrxR) and cathepsin B (cat B), important targets in cancer chemotherapy [28]. TrxR was chosen as it is highly relevant with respect to gold-based drugs (see below) and cat B is implicated in various stages of metastasis which correlate to the observed in vitro effects of RAPTA-T [29], It turned out that while the selected compounds (Fig. 3) are not inhibitors of TrxR with the exception of carboRAPTA-C, they are active inhibitors of cat B [28],... 

With respect to the pharmacokinetics and pharmacodynamics of specific cancer chemotherapy drugs in older patients, the goal is to achieve a desired tissue exposure to the drug(s) in the context of the age-related changes in drug disposition described in other sections of this chapter. Specific for anticancer... 

A number of animal model systems have been developed to provide tumor microenvironments that mimic the clinical situation. However, there are no perfect animal models for drug development. The adequacy of any specific animal model depends on its validity, selectivity, predictability, and reproducibility (22). In cancer chemotherapy, animal models are selected to simultaneously demonstrate antitumor efficacy and evaluate systemic toxicities in an intact organism. Ideally, the tumor system under study in the animal model should be genetically stable over time, with homogeneous characteristics that mimic human tumor biology. In oncology, a variety of diverse animal models for human tumors have been developed. These models can be broadly categorized in to three... 

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