Against P-388 mouse lymphoma

Malevamide D 137, a highly cytotoxic peptide ester from a Hawaiian marine cyanobaeterium of Symploca hydnoides, showed IC50 values of 0.3-0.7 nM (0.2-0.5 ng/mL) against P-388 (mouse lymphoma), A-549 (human lung carcinoma), and HT-29 (human colon carcinoma) cell lines and 0.7 nM against the MEL-28(human melanoma) eell line. ... [Pg.232]

Conicol was a meroterpenoid isolated from the ascidian Aplidium conicum collected from Tarifa Island. In Salva et al. s study, cytotoxicity assays performed on P-388 mouse lymphoma, A-549 human lung carcinoma, and HT-29 human colon carcinoma cell lines of the organic extract of A. conicum showed a moderate but selective activity against the P-388 tumor cell line with IC50 of 5 fig/mL. In addition, (-l-)-epiconicol, a marine metabolite, was isolated from Aplidium off. densum and exhibited... [Pg.603]

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