Selection affinity

Regnier, F. E. Riggs, L. Zhang, R. Xiong, L. Liu, P. Chakraborty A. Seeley E. Sioma, C. Thompson, R. A. Comparative proteomics based on stable isotope labeling and affinity selection. J. Mass. Spectrom. 2002,37,133-145. 

Geng, M., Zhang, X., Bina, M., Regnier, F. (2001). Proteomics of glycoproteins based on affinity selection of glycopeptides from tryptic digests. J. Chromatogr. B 752, 293-306. 

Amini, A., Chakraborty, A., Regnier, F.E. (2002). Simplification of complex tryptic digests for capillary electrophoresis by affinity selection of histidine-containing peptides with immobilized metal ion affinity chromatography. J. Chromatogr. B 772, 35-44. 

Figure 16.4 Graph depicting the percentage of lysine residues among peptides that bind to the indicated monoclonal antibodies. The peptides were isolated after affinity selection (biopanning) from a phage-displayed combinatorial peptide library. The peptides are grouped as to whether they are susceptible to formalin fixation, resulting in a loss of immunoreactivity.

Rhode, B.M., Hartmuth, K., Urlaub, H., and Liihrmann, R. (2003) Analysis of site-specific protein-RNA cross-links in isolated RNP complexes, combining affinity selection and mass spectrometry. RNA 9, 1542. 

Affinity driven molecular transfer (ADMT) system, 78 264-265 Affinity ligands, 6 390 types of, 6 393-394, 396t Affinity method, 10 339 Affinity resins, 20 197 Affinity-selected libraries, 72 515-517 Affymatrix GeneChip HFV PRT, 76 390 Aflatoxins, 72 84... 

Menziani, M.C., Cocchi, M., Fanelli, F. and De Benedetti, P.G. (1995) Quantitative structure-affinity/ selectivity relationship analysis on three-dimensional models of the complexes between the ETA and ETB receptors and C-terminal endothelin hexapeptide antagonists. Journal of Molecular Structure (Theochem), 333, 243—248. 

S., Marwood, R., Patel, S., Thomas, S., Hitzel, L, O Connor, D., Szeto, N., Castro, J.L., Hutson, P.H. and MacLeod, A.M. (2001) 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, orally bioavailable h5-HT2A receptor antagonists. Journal of Medicinal Chemistry, 44, 1603-1614. 

Lopez-Rodriguez, M.L., Morcillo, M.J., Fernandez, E., Porras, E., Murcia, M., Sanz, A.M. and Orensanz, L. (1997) Synthesis and structure-activity relationships of a new model of arylpiperazines. 3.2-[o-(4-Arylpiperazin-l-yl)alkyl]perhydropyrrolo-[l,2-c] imidazoles and -perhydroimidazo[l,5-a] pyridines study of the influence of the terminal amide fragment on 5-HTiA affinity/selectivity. Journal of Medicinal Chemistry, 40, 2653—2656. 

Baringhaus, K.H. and Matter, H. Efficient strategies for lead optimization by simultaneously addressing affinity, selectivity and pharmacokinetic parameters. In Chemoinformatics in Drug Discovery, Oprea, T.I. (Ed.). Wiley-VCH, Weinheim, 2004, 333-379. 

Efficient Strategies for Lead Optimization by Simultaneously Addressing Affinity, Selectivity and Pharmacokinetic Parameters... 

In particular, parallel optimization of affinity/selectivity and pharmacokinetic properties are difficult to achieve, especially if several PK parameters need to be... 

On the basis of their evaluation and our internal predictive VolSurf model [160] for this series (r 0.81, q 0.60, 4 PLS components), it can be concluded that factors like size and shape, which had previously been reported to affect paracellular permeability, are indeed important in the VolSurf PLS model to explain the local structure-permeability relationship of one particular scaffold. Hence, local statistical models provide a qualitative ranking of candidates, and thus are valuable for optimization of pharmaceutically relevant compounds, especially if combined with additional models to understand affinity, selectivity or any particular pharmacokinetic behavior. 

ALIS An Affinity Selection-Mass Spectrometry System for the Discovery and Characterization of Protein-Ligand Interactions... 

The schematic shown in Fig. 3.1 describes an optimized, integrated SEC-RPC-MS-based affinity selection platform developed at NeoGenesis, dubbed the... 

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