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Selectivity integrin affinities

Selected examples of peptide and nonpeptide leads that have high affinity for integrin av/33 with IC50 values in the nanomolar or subnanomolar range, and are potential candidates as targeting BMs to carry the radionuclide to tumors,... [Pg.200]

A Via-selective antagonist with a carboxyl-terminal extension providing the integrin anatgonist sequence RGDF. Retains high affinity (K = 0.4 nM) for the Vj vasopressin receptor. Antagonizes both uterotonic (PA2 = 7.8) and pressor (PA2 = 7.2) activities of oxytocin and vasopressin respectively (35). [Pg.31]

KadiiwagiH, Eigenthaler E, Schwartz MA, etal. Affinity modulation ofplatelet integrin alpha lib beta 3 endonexin, a selective binding partner of the beta 3 integrin cytoplasntic tail. J Cell Biol 1997 137 1433-1443. [Pg.184]

An additional problem with linear peptides is non-selectivity against other integrin receptors as mentioned earlier, GRGDS is a weak inhibitor of platelet aggregation (IC50 = 25/rM), but has affinity for the vitronectin receptor otv/ 3 as well as aMb 3 [33]. [Pg.42]

See other pages where Selectivity integrin affinities is mentioned: [Pg.38]    [Pg.201]    [Pg.38]    [Pg.512]    [Pg.279]    [Pg.359]    [Pg.239]    [Pg.38]    [Pg.117]    [Pg.181]    [Pg.261]    [Pg.281]    [Pg.270]    [Pg.175]    [Pg.60]    [Pg.197]    [Pg.402]    [Pg.423]    [Pg.200]    [Pg.208]    [Pg.209]    [Pg.483]    [Pg.1336]    [Pg.304]    [Pg.340]    [Pg.272]    [Pg.168]    [Pg.329]    [Pg.37]    [Pg.1259]    [Pg.290]    [Pg.314]    [Pg.511]    [Pg.364]    [Pg.54]    [Pg.184]    [Pg.313]    [Pg.290]    [Pg.314]    [Pg.614]    [Pg.415]    [Pg.19]    [Pg.1315]    [Pg.332]   
See also in sourсe #XX -- [ Pg.56 ]



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