Affective disorders 294 amphetamine

Sherry RL, Rauw G, McKenna KF, Paetsch PR, Courts RT, et al. 2000. Failure to detect amphetamine or 1-amino-3-phenylpropane in humans or rats receiving the MAO inhibitor tranylcypromine. J Affect Disord 61 23. 

Nolen WA, Haffmans PMJ, Bouvy PF, et al Monoamine oxidase inhibitors in resistant major depression. J Affect Disord 28 189-197, 1993 Nomikos GC, Damsma G, Wenkstern D, et al Chronic desipramine enhances amphetamine-induced increases in interstitial concentrations of dopamine in the nucleus accumbens. Eur J Pharmacol 195 63-73, 1991 Nomikos GC, Damsma D, Wenkstern D, et al Effects of chronic bupropion on interstitial concentrations of dopamine in rat nucleus accumbens and striatum. Neuropsychopharmacology 7 7-14, 1992... 

For decades researchers have looked at whether intoxication with certain drugs could mimic the signs and symptoms of schizophrenia. Amphetamines increase dopamine release and can induce some positive symptoms like paranoia. Lysergic acid diethylamide (LSD) affects 5-HT receptors but tends to induce visual perception changes and not frank hallucinations. Phencyclidine (PCP), however, induces a state in healthy controls that seems very similar to schizophrenia. This includes thought disorder and negative symptoms... 

Q7 Other conditions which may present similar symptoms include drug-induced psychosis such as one brought on by lysergic acid diethylamide, or LSD, or amphetamine, personality disorder or affective psychosis. In older patients dementia may present with schizophrenia-like symptoms, but these patients usually have significant memory deficits, which do not occur in schizophrenia. 

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